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[Penetration and action of edoxudine in vitro and in vivo]
R Kaul1, B Hempel, E De Clercq
1Biochemische und Analytische Abteilung der Robugen GmbHa, Esslingen/Neckar, Leuven, Belgien.
Arzneimittel-Forschung
|March 1, 1989
Abstract:
The penetration of 5-ethyl-2'-deoxyuridine (edoxudine, Aedurid) from gel base with and without the addition of urea and other adjuvant has been studied in an in vitro model using guinea pig skin. The formulation of 3% edoxudine gel with 5% urea showed the best results. In vivo experiments on hairless mice infected intracutaneously with herpes simplex virus type 1 also showed this formulation's good efficacy as compared to other formulations.