Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Polygenic Traits01:18

Polygenic Traits

70.1K
When more than one gene is responsible for a given phenotype, the trait is considered polygenic. Human height is a polygenic trait. Studies have uncovered hundreds of loci that influence height, and there are believed to be many more. Due to the high number of genes involved, as well as environmental and nutritional factors, height varies significantly within a given population. The distribution of height forms a bell-shaped curve, with relatively few individuals in the population at the...
70.1K
Polygenic Traits01:18

Polygenic Traits

11.3K
11.3K
Human Genetics01:28

Human Genetics

1.8K
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
1.8K
Principles of Pharmacogenetics: Types of Genetic Variants01:27

Principles of Pharmacogenetics: Types of Genetic Variants

73
The human genome is over 99.9% identical between individuals, yet genetic differences exist at millions of bases. The human genome contains approximately 3 million variant positions per individual, many of which are heterozygous, contributing to genetic diversity and individual traits. Genetic variations include single-nucleotide polymorphisms (SNPs), insertions, deletions, and copy number variations (CNVs).SNPs, the most common variation, involve single-base changes in DNA. These can be...
73
Incomplete Dominance01:43

Incomplete Dominance

32.0K
Gregor Mendel's work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid cell has two variants called alleles inherited from each parent. He suggested that amongst these two alleles, one allele is dominant in character and the other recessive. The combination of alleles determines the phenotype of a gene in an organism.
32.0K
Behavioral Genetics and Its Designs01:23

Behavioral Genetics and Its Designs

1.2K
Behavior genetics explores how genetic inheritance influences human behavior. It focuses on how genes, passed from parents to offspring, contribute to the development of behavioral traits and tendencies. This branch of genetics seeks to understand the complex interplay between inherited genetic factors and environmental influences in shaping our behaviors.
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...
1.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sex-Specific Polygenic Risk Scores and Replication in a Model-Free Analysis of Schizophrenia Data.

Genes·2025
Same author

Digenic Analysis Finds Highly Interactive Genetic Variants Underlying Polygenic Traits.

Medical research archives·2024
Same author

A multi-threaded approach to genotype pattern mining for detecting digenic disease genes.

Frontiers in genetics·2023
Same author

Overview of frequent pattern mining.

Genomics & informatics·2023
Same author

Comorbidity of Novel <i>CRHR2</i> Gene Variants in Type 2 Diabetes and Depression.

International journal of molecular sciences·2022
Same author

Implication of Melanocortin Receptor Genes in the Familial Comorbidity of Type 2 Diabetes and Depression.

International journal of molecular sciences·2022

Related Experiment Video

Updated: Mar 15, 2026

In Vivo Modeling of the Morbid Human Genome using Danio rerio
12:31

In Vivo Modeling of the Morbid Human Genome using Danio rerio

Published on: August 24, 2013

21.4K

Polygenic Models for Risk Prediction in Human Genetics.

Jurg Ott

    Human Heredity
    |September 1, 2016
    PubMed
    Summary
    This summary is machine-generated.

    This study evaluates Fisher's additive polygenic model and introduces a finite polygenic model. The research explores its application in understanding schizophrenia recurrence risks.

    More Related Videos

    Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
    05:53

    Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

    Published on: June 21, 2018

    10.8K
    Mapping Alzheimer's Disease Variants to Their Target Genes Using Computational Analysis of Chromatin Configuration
    04:41

    Mapping Alzheimer's Disease Variants to Their Target Genes Using Computational Analysis of Chromatin Configuration

    Published on: January 9, 2020

    19.5K

    Related Experiment Videos

    Last Updated: Mar 15, 2026

    In Vivo Modeling of the Morbid Human Genome using Danio rerio
    12:31

    In Vivo Modeling of the Morbid Human Genome using Danio rerio

    Published on: August 24, 2013

    21.4K
    Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
    05:53

    Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

    Published on: June 21, 2018

    10.8K
    Mapping Alzheimer's Disease Variants to Their Target Genes Using Computational Analysis of Chromatin Configuration
    04:41

    Mapping Alzheimer's Disease Variants to Their Target Genes Using Computational Analysis of Chromatin Configuration

    Published on: January 9, 2020

    19.5K

    Area of Science:

    • Quantitative genetics
    • Human genetics
    • Psychiatric genetics

    Background:

    • Fisher's additive polygenic inheritance model is a foundational concept in quantitative genetics.
    • Alternative models, such as the polygenic threshold model, offer different perspectives on complex trait inheritance.
    • Understanding genetic contributions to diseases like schizophrenia is crucial for public health.

    Purpose of the Study:

    • To critically evaluate Fisher's additive polygenic inheritance model.
    • To explore alternative polygenic inheritance models, including the polygenic threshold model.
    • To develop and apply a finite polygenic model to human genetic data, specifically for schizophrenia recurrence risks.

    Main Methods:

    • Literature review of polygenic models in human genetics.
    • Development of a novel finite polygenic model.
    • Application of the developed model to analyze recurrence risks in schizophrenia.

    Main Results:

    • A comprehensive review of existing polygenic inheritance models was conducted.
    • A new finite polygenic model was formulated and detailed.
    • The study discusses the model's applicability to schizophrenia recurrence data.

    Conclusions:

    • The developed finite polygenic model provides a framework for analyzing complex genetic traits.
    • This approach offers insights into the genetic architecture of schizophrenia.
    • Further research can refine the model for broader applications in psychiatric genetics.