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Patient-related factors that influence coronary artery density in CCTA: a retrospective clinical study
Peng Cao1, Miao He1, Chen Qiao1
1Department of Radiology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
Insights
Coronary artery attenuation on CCTA is linked to patient weight, BMI, and cardiac output. Higher values in these factors correlate with lower coronary artery attenuation.
Area of Science:
- Cardiovascular Imaging
- Radiology
- Biomedical Engineering
Background:
- Coronary artery assessment using coronary CT angiography (CCTA) is crucial for diagnosing cardiovascular diseases.
- Understanding factors influencing coronary artery visualization is key to accurate interpretation.
Purpose of the Study:
- To investigate the relationship between patient-specific physical factors and cardiac hemodynamic parameters with coronary artery attenuation on CCTA.
- To identify predictors of coronary artery density in patients undergoing CCTA.
Main Methods:
- Retrospective analysis of 64 patients undergoing CCTA.
- Recorded physical factors (height, body weight, BMI, blood pressure) and cardiac hemodynamic parameters (heart rate, myocardial mass, cardiac output, ejection fraction, volumes).
- Evaluated the correlation between left main artery attenuation and patient-related factors.
Main Results:
- Significant negative linear correlations observed between left main artery attenuation and body weight, BMI, cardiac output, end-diastolic volume, and myocardial mass.
- Established significant correlations between cardiac output and heart rate, end-diastolic volume and body weight, and myocardial mass and body weight.
Conclusions:
- Patient body weight, body mass index, and cardiac function significantly influence coronary artery attenuation on CCTA.
- Coronary artery attenuation is dependent on the patient's physical characteristics and cardiac status.
Objectives:
The aim of this study was to investigate the relationship between various patient-related factors (physical and cardiac hemodynamic parameters) and the coronary artery density on coronary CT angiography (CCTA).
Methods:
A total of 64 patients (female: male ratio, 24:40; age, 58.2 years±9.3, age range, 31-81 years; mean body weight, 65.3 kg±11.6, range 40-88 kg) were effectively enrolled in this approved retrospective study. Patient-related physical factors including height, body weight (BW), body mass index (BMI), systolic blood pressure (BPsys), diastolic blood pressure (BPdis) and blood pulse pressure (Bp) were recorded, measured and calculated prior to the administration of contrast media during the CCTA. Patient-related cardiac hemodynamic parameters, including heart rate (HR), myocardial mass (MM), cardiac output (CO), ejection fraction (EF), end-diastolic dimension (EDV), end-systolic volume (ESV) and stroke volume (SV), were analysed and recorded on the multimodality workplace (MMWP). The mean attenuation values of the left main artery (LMA) were measured and calculated. The correlation of the mean attenuation in the coronary arteries with the physical and hemodynamic parameters was evaluated. The correlations between the physical factors and hemodynamic parameters were also calculated.
Results:
A significant negative linear correlation was found between the attenuation of the left main artery (LMA) and BW (P=.001), BMI (P=.006), CO (P=.008), EDV (P=.001) and MM (P<.001). Significant linear correlations were obtained between CO and HR (P<.001), EDV and BW (P=.001) and MM and BW (P<.001).
Conclusion:
Coronary artery attenuation depends on the patient's specific physical and cardiac function status.
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