Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hormones and Bone Tissue01:17

Hormones and Bone Tissue

4.1K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
4.1K
The Parathyroid Glands00:59

The Parathyroid Glands

5.6K
The two pairs of parathyroid glands embedded within the posterior surface of the thyroid gland are restricted by a dense capsule around them. These glands comprise two distinct cell populations—parathyroid oxyphil and parathyroid principal cells- pivotal in calcium homeostasis.
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by...
5.6K
Bone Remodeling01:40

Bone Remodeling

40.9K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
40.9K
Skeleton and Calcium Homeostasis01:21

Skeleton and Calcium Homeostasis

6.5K
Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
6.5K
Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

714
Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
714
Imaging Studies III: Computed Tomography01:27

Imaging Studies III: Computed Tomography

565
DefinitionComputed Tomography (CT) of the genitourinary (GU) tract is a non-invasive imaging modality that utilizes X-rays and computer processing to generate detailed cross-sectional images of the urinary system, encompassing the kidneys, ureters, bladder, and adjacent structures such as the adrenal glands.PurposeCT scans of the GU tract serve several diagnostic and therapeutic purposes, including:Diagnosis of Urinary Tract Diseases: Detects kidney stones, tumors, cysts, and congenital...
565

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The ethanolic extract of Gomphrena celosioides is not carcinogenic and has antigenotoxic effects and chemopreventive Properties.

Brazilian journal of biology = Revista brasleira de biologia·2024
Same author

Revisiting the endocrine and metabolic manifestations of COVID-19 two years into the pandemic.

Reviews in endocrine & metabolic disorders·2022
Same author

Trabecular bone score in women with differentiated thyroid cancer on long-term TSH-suppressive therapy.

Journal of endocrinological investigation·2021
Same author

A Simple Formula to Estimate Parathyroid Weight on 4D-CT, Predict Pathologic Weight, and Diagnose Parathyroid Adenoma in Patients with Primary Hyperparathyroidism.

AJNR. American journal of neuroradiology·2020
Same author

Consensus statement from 2<sup>nd</sup> International Conference on Controversies in Vitamin D.

Reviews in endocrine & metabolic disorders·2020
Same author

Hypercalciuria: its value as a predictive risk factor for nephrolithiasis in asymptomatic primary hyperparathyroidism?

Journal of endocrinological investigation·2019
Same journal

Correction to: Melatonin at pharmacological concentrations suppresses osteoclastogenesis via the attenuation of intracellular ROS.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2026
Same journal

Letter to the Editor: multiplicity, microbiome interventions, and measurement biases in bone health biomarkers.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2026
Same journal

Association between myosteatosis and bone mineral density in postmenopausal women.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2026
Same journal

Author response to the letter to the editor regarding "Hip Response to Romosozumab in Glucocorticoid Users: Beyond Systemic Bone Turnover Markers".

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2026
Same journal

Preventing post-denosumab bone loss with zoledronate: a 2-year randomized trial in post-menopausal women without and with pre-exposure to bisphosphonates.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2026
Same journal

Revisiting the Osteoporosis Self-Assessment Tool (OST): evidence from a multi-cohort study in Asia supporting age-dependent thresholds.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2026
See all related articles

Related Experiment Video

Updated: Mar 15, 2026

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy
03:57

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy

Published on: July 14, 2023

2.4K

Bone imaging in hypoparathyroidism.

B C Silva1,2, M R Rubin3, N E Cusano3

  • 1Department of Medicine, UNI BH, Felicio Rocho Hospital and Santa Casa de Belo Horizonte, Belo Horizonte, Brazil. barbarasilva2131@gmail.com.

Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
|September 1, 2016
PubMed
Summary
This summary is machine-generated.

Hypoparathyroidism (HypoPT) causes reduced bone remodeling, leading to higher bone density but unclear fracture risk. Parathyroid hormone (PTH) treatment improves remodeling but its effect on fractures is unknown.

Keywords:
Bone microarchitectureBone mineral densityBone strengthFracture riskHypoparathyroidismPTH

More Related Videos

Establishment of a Simple and Effective Rat Model for Intraoperative Parathyroid Gland Imaging
07:12

Establishment of a Simple and Effective Rat Model for Intraoperative Parathyroid Gland Imaging

Published on: August 17, 2022

5.1K
Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation
07:13

Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation

Published on: March 14, 2017

15.4K

Related Experiment Videos

Last Updated: Mar 15, 2026

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy
03:57

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy

Published on: July 14, 2023

2.4K
Establishment of a Simple and Effective Rat Model for Intraoperative Parathyroid Gland Imaging
07:12

Establishment of a Simple and Effective Rat Model for Intraoperative Parathyroid Gland Imaging

Published on: August 17, 2022

5.1K
Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation
07:13

Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation

Published on: March 14, 2017

15.4K

Area of Science:

  • Endocrinology
  • Bone Metabolism
  • Skeletal Biology

Background:

  • Hypoparathyroidism (HypoPT) is characterized by parathyroid hormone (PTH) deficiency, profoundly reducing bone remodeling.
  • Patients with HypoPT exhibit higher bone mineral densities (BMDs) and normal trabecular bone score (TBS).
  • Advanced imaging reveals increased cortical bone mineral density but reduced thickness and porosity in HypoPT.

Purpose of the Study:

  • To review skeletal involvement in HypoPT.
  • To evaluate the effects of parathyroid hormone (PTH) treatment on bone health in HypoPT.
  • To assess bone strength and fracture risk in HypoPT patients.

Main Methods:

  • Dual-energy X-ray absorptiometry (DXA) for BMD.
  • Trabecular Bone Score (TBS) for microarchitecture.
  • Peripheral quantitative computed tomography (pQCT) and high-resolution pQCT (HRpQCT) for detailed bone structure.

Main Results:

  • HypoPT subjects show elevated BMD at all sites, particularly the lumbar spine.
  • Cortical bone is denser but thinner with lower porosity; trabeculae are more numerous yet thinner.
  • PTH therapy improves bone remodeling and transiently increases estimated bone strength.

Conclusions:

  • Skeletal abnormalities in HypoPT are significant, with higher bone density but uncertain fracture risk.
  • The impact of PTH therapy on fracture risk in HypoPT remains undetermined.
  • Further research is needed to clarify bone strength and fracture outcomes in HypoPT.