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Updated: Mar 15, 2026

Author Spotlight: Alleviating Nausea and Vomiting in Pregnancy with Safe and Effective Auricular Acupuncture
Published on: August 4, 2023
A novel approach to hyperemesis gravidarum: evaluation by a visual analogue scale score and treatment with
1Dipartimento di Ostetricia e Neonatologia, Servizio di Medicina Interna, Ospedale Sant'Anna, Università di Torino , Torino , Italy.
Objective:
A preliminary report on the symptomatic effect of clonidine in severe hyperemesis gravidarum (HG).
Design:
Observational.
Settting:
Hospital based: Ospedale Sant'Anna, Torino, Italy.
Population:
Twelve pregnant women, 8-16 weeks, affected by severe, refractory HG.
Methods:
Assessment by two clinical score indexes: Pregnancy Unique Quantification of Emesis (PUQE) score and a Visual Analogue Scale (VAS) 5-item questionnaire, filled out daily, to detect subjective improvement or worsening of symptoms.
Main Outcome Measures:
PUQE score and VAS score before and after transdermal clonidine treatment.
Results:
We found substantial improvement of symptoms and severity score indexes after four and 14 days. The comparison of pretreatment and post-treatment scores shows a significant statistical difference P < 0.0001.
Conclusion:
Transdermal clonidine may be considered as a treatment for resistant severe HG.
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