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Updated: Mar 15, 2026

Assessment of Maternal Vascular Remodeling During Pregnancy in the Mouse Uterus
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Assessment of Maternal Vascular Remodeling During Pregnancy in the Mouse Uterus

Published on: December 5, 2015

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Moyamoya disease in pregnancy: maintenance of maternal blood pressure

Helen L Barrett1, Karin Lust2, Narelle Fagermo2

  • 1University of Queensland, UQ Centre for Clinical Research, Herston, Queensland, Australia, 4029; University of Queensland, School of Medicine, North, Herston, Queensland, Australia, 4029; Obstetric Medicine, Internal Medicine and Aged Care Services, Royal Brisbane and Women's Hospital, Herston, Queensland, Australia, 4029.

Obstetric Medicine
|September 1, 2016
PubMed

Moyamoya disease is a rare cerebrovascular occlusive disorder characterized by stenosis in the circle of Willis with the development of a compensatory circulation. It has been associated with significant morbidity in pregnancy including intracranial haemorrhage, ischaemic stroke and epilepsy. We present the case of a 26-year-old woman with a previous diagnosis of moyamoya vasculopathy with bilateral superficial temporal to middle cerebral artery bypass grafting. During the second trimester, she developed significant neurological symptoms related to postural hypotension in the presence of a stenosis of the right-sided graft. The hypotension was treated with fludrocortisone therapy with improvement in blood pressure and symptoms. Moyamoya vasculopathy poses unique challenges to obstetric care. This is the first report of use of fludrocortisone for maintenance of blood pressure during pregnancy in this condition.

Keywords:
cerebral artery bypass graftingfludrocortisonehypotensionmoyamoya diseasepregnancy

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