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Updated: Mar 15, 2026

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A Sustainable and Efficient Synthesis of Benzyl Phosphonates Using PEG/KI Catalytic System
Shamrao Disale1, Sandip Kale2, George Abraham2
1Department of Chemistry, Institute of Chemical Technology Mumbai, India.
Abstract:
An efficient and expedient protocol for the synthesis of benzyl phosphonates using KI/K2CO3 as a catalytic system and PEG-400 as benign solvent has been developed. The reaction proceeds smoothly at room temperature achieving excellent selectivity and yield of the corresponding products. The combination of PEG-400, KI, and K2CO3 in this reaction avoids the need of volatile/toxic organic solvents and reactive alkali metals or metal nanoparticles/hydrides. We believe that this benign combination (PEG-400 and KI) could be used for other related organic transformations.
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