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The Diagnosis of Iliac Bone Destruction in Children: 22 Cases from Two Centres
Xiangshui Sun1, Yue Lou2, Xiaodong Wang3
1Department of Orthopedics Surgery, Children's Hospital of SooChow University, Suzhou 215003, China; Department of Orthopedics Surgery, Nanjing Children's Hospital, Nanjing Medical University, Nanjing 210008, China.
Insights
Pediatric iliac bone destruction is rare, with metastatic neuroblastoma and eosinophilic granuloma being the most frequent causes. Accurate diagnosis requires careful analysis of clinical, imaging, and histopathological findings.
Area of Science:
- Pediatric Oncology
- Musculoskeletal Radiology
- Pediatric Pathology
Background:
- Iliac bone destruction in children is an uncommon condition.
- Diagnosis is challenging due to diverse clinical and imaging presentations.
Purpose of the Study:
- To retrospectively analyze clinical features, imaging findings, and histopathological diagnoses of childhood iliac bone destruction.
- To identify common causes and diagnostic patterns.
Main Methods:
- Retrospective analysis of 22 pediatric cases from July 2007 to April 2015.
- Evaluation of clinical data, imaging (bone destruction patterns, soft tissue mass), and histopathology.
- Descriptive statistical analysis of collected data.
Main Results:
- Identified common causes: metastatic neuroblastoma (8 cases), eosinophilic granuloma (7 cases).
- Other diagnoses included Ewing's sarcoma (2), osteomyelitis (2), bone cyst (1), fibrous dysplasia (1), and non-Hodgkin's lymphoma (1).
- Detailed analysis of lesion characteristics and soft tissue involvement was performed.
Conclusions:
- Childhood iliac bone destruction has varied etiologies.
- Metastatic neuroblastoma and eosinophilic granuloma are the predominant causes in this pediatric cohort.
- Comprehensive evaluation integrating clinical, imaging, and pathological data is crucial for accurate diagnosis.
Abstract:
Iliac bone destruction in children is uncommon and presents various imaging features. Correct diagnosis based on clinical and imaging features is difficult. This research aimed to retrospectively explore the clinical features, imaging, and histopathological diagnosis of children with iliac bone destruction. A total of 22 children with iliac bone destruction were enrolled in this retrospective analysis from two children's hospitals during July 2007 to April 2015. Clinical features, imaging, and histopathological findings were analysed. The mode of iliac bone destruction, lesion structure, and the relationship between the range of soft tissue mass and cortical destruction were determined based on imaging data. The data were analysed using descriptive methods. Of the iliac bone destruction cases, eight cases were neuroblastoma iliac bone metastasis, seven cases were bone eosinophilic granuloma, two cases were Ewing's sarcoma, two cases were osteomyelitis, one case was bone cyst, one case was bone fibrous dysplasia, and one case was non-Hodgkin's lymphoma. Iliac bone destruction varies widely in children. Metastatic neuroblastoma and eosinophilic granuloma are the most commonly involved childhood tumours.
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