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Autoimmune progesterone dermatitis responding to Tamoxifen
C J Stephens1, F T Wojnarowska, J D Wilkinson
1Wycombe General Hospital, U.K.
The British Journal of Dermatology
|July 1, 1989
Summary
Autoimmune progesterone dermatitis, a rare condition, worsened with progesterone exposure. Treatment with Tamoxifen, an anti-oestrogen drug, led to significant improvement.
Area of Science:
- Reproductive immunology
- Dermatology
- Endocrinology
Background:
- Autoimmune progesterone dermatitis is a rare hypersensitivity reaction.
- Symptoms often correlate with the menstrual cycle and progesterone levels.
Observation:
- A patient presented with symptoms of autoimmune progesterone dermatitis.
- Skin condition exacerbated premenstrually and following progesterone challenge (intramuscular and oral).
Findings:
- The condition did not respond to oestrogen therapy.
- Significant clinical improvement was observed after treatment with Tamoxifen, an anti-oestrogen medication.
Implications:
- Tamoxifen may be an effective therapeutic option for autoimmune progesterone dermatitis.
- Further research into progesterone hypersensitivity and its management is warranted.