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Related Experiment Video

Updated: Mar 15, 2026

An in vivo Assay to Test Blood Vessel Permeability
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Measuring Vascular Permeability In Vivo.

Eelco F J Meijer1, James W Baish1,2, Timothy P Padera1

  • 1Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, 100 Blossom Street, Boston, MA, 02114, USA.

Methods in Molecular Biology (Clifton, N.J.)
|September 2, 2016
PubMed
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This study compares conventional 2D and novel 3D imaging methods for measuring in vivo vascular permeability. These techniques are crucial for understanding tumor vasculature and improving therapeutic agent delivery.

Area of Science:

  • Biomedical Engineering
  • Physiology
  • Medical Imaging

Background:

  • In vivo vascular permeability measurements are vital for understanding physiological and pathophysiological conditions.
  • These measurements inform research on angiogenesis, tumor vasculature, and drug delivery efficacy.

Purpose of the Study:

  • To describe and discuss a conventional 2D imaging method for measuring vascular permeability.
  • To present a recently developed 3D imaging method that advances existing approaches.

Main Methods:

  • Review and discussion of a 2D imaging method (Gerlowski and Jain, 1986; Yuan et al., 1990s).
  • Description and advancement of a 3D imaging method based on Brown et al. (2001).

Main Results:

Keywords:
Intravital fluorescence microscopyMultiphoton microscopyVascular normalizationVascular permeability

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  • The study details established 2D and novel 3D imaging techniques for assessing vascular permeability.
  • The 3D method represents an advancement over the original 2D approaches.

    • Conclusions:

    • Both 2D and 3D imaging methods offer valuable insights into in vivo vascular permeability.
    • The development of 3D imaging enhances the capability to study complex vascular dynamics.