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Updated: Mar 15, 2026

Clinical Imaging of Microwave Mammography

Clinical Imaging of Microwave Mammography

Published on: November 14, 2025

Growing concern following compression mammography.

Johannes Pieter van Netten¹, Stephen Hoption Cann², Ian Thornton¹

¹Department of Biology, University of Victoria, Victoria, British Columbia, Canada.

BMJ Case Reports

|September 2, 2016

Summary

Mammography compression may have influenced the aggressive progression of an undiagnosed breast cancer, leading to a rare inflammatory carcinoma. This case highlights the need to consider mechanical forces in tumor development and progression.

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Area of Science:

Oncology
Radiology
Pathology

Background:

Mammography is a standard screening tool for breast cancer.
Undiagnosed breast cancer can exist without clinical symptoms.

Observation:

A patient developed intense pain, swelling, and a hematoma after mammography compression.
A large mass developed three months later, diagnosed as necrotizing high-grade ductal carcinoma.
The tumor was an aggressive, HER2-positive inflammatory carcinoma (Stage IIIC).

Findings:

The patient experienced rapid tumor progression and recurrence despite chemotherapy, trastuzumab, and radiotherapy.
The tumor was oestrogen and progesterone receptor negative, but highly HER2 positive.
The patient died from progressive disease two years after diagnosis.

Implications:

This case raises questions about the potential influence of mammography compression on the natural history of undiagnosed breast cancer.
Further research is needed to understand the biomechanical effects of mammography on tumor behavior.
Consideration of mechanical stress in tumor development may offer new perspectives in oncology.