Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Simulated Microgravity Suppresses Proline Biosynthesis in Skin Fibroblasts to Impair Skin Structure.

Skin pharmacology and physiology·2026
Same author

Nuclear envelope rupture and DNA damage driven by high pressure are mediated by F-actin and induce hepatocyte inflammation via cGAS-STING.

International immunopharmacology·2025
Same author

The Role of Plectin Dysregulation in Cancer: Recent Advances.

Molecules (Basel, Switzerland)·2025
Same author

Matrix stiffness-driven cancer progression and the targeted therapeutic strategy.

Mechanobiology in medicine·2025
Same author

Role and mechanisms of m6A demethylases in digestive system tumors.

American journal of cancer research·2025
Same author

Matrix stiffening induces hepatocyte functional impairment and DNA damage via the Piezo1‒ERK1/2 signaling pathway.

Journal of physiology and biochemistry·2025
Same journal

Age-related morphological and histological changes in the dromedary camel thymus.

Histology and histopathology·2026
Same journal

Isofraxidin ameliorates CCl<sub>4</sub>-induced liver fibrosis in mice by inhibiting the NF-κB pathway.

Histology and histopathology·2026
Same journal

FOXO3/HMOX1 axis promotes melanoma progression by regulating ferroptosis and immune escape.

Histology and histopathology·2026
Same journal

Immunohistochemical evaluation of CD44 expression and its correlation with clinicopathological factors and molecular markers (EGFR, STAT3, and lipid metabolism-related proteins) in oral squamous cell carcinoma.

Histology and histopathology·2026
Same journal

Betulinic acid mitigates septic cardiomyopathy in mice through modulating the TLR4/MyD88/NF-κB signaling axis and NLRP3 inflammasome pathway.

Histology and histopathology·2026
Same journal

Extension loss following ACL reconstruction: A narrative review of mechanisms and phase-specific management.

Histology and histopathology·2026
See all related articles

Related Experiment Video

Updated: Mar 15, 2026

Chondrogenic Differentiation Induction of Adipose-derived Stem Cells by Centrifugal Gravity
08:30

Chondrogenic Differentiation Induction of Adipose-derived Stem Cells by Centrifugal Gravity

Published on: February 24, 2017

10.1K

Microgravity directs stem cell differentiation.

Zhe Chen1, Qing Luo1, Lin Yuan1,2

  • 1Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing, China.

Histology and Histopathology
|September 2, 2016
PubMed
Summary
This summary is machine-generated.

Microgravity significantly impacts stem cell differentiation, crucial for tissue regeneration and regenerative medicine. Understanding these effects is key to advancing therapies in space and on Earth.

More Related Videos

Propagation of Dental and Respiratory Cells and Organs in Microgravity
06:29

Propagation of Dental and Respiratory Cells and Organs in Microgravity

Published on: May 25, 2021

2.5K
Stencil Micropatterning of Human Pluripotent Stem Cells for Probing Spatial Organization of Differentiation Fates
08:07

Stencil Micropatterning of Human Pluripotent Stem Cells for Probing Spatial Organization of Differentiation Fates

Published on: June 17, 2016

9.0K

Related Experiment Videos

Last Updated: Mar 15, 2026

Chondrogenic Differentiation Induction of Adipose-derived Stem Cells by Centrifugal Gravity
08:30

Chondrogenic Differentiation Induction of Adipose-derived Stem Cells by Centrifugal Gravity

Published on: February 24, 2017

10.1K
Propagation of Dental and Respiratory Cells and Organs in Microgravity
06:29

Propagation of Dental and Respiratory Cells and Organs in Microgravity

Published on: May 25, 2021

2.5K
Stencil Micropatterning of Human Pluripotent Stem Cells for Probing Spatial Organization of Differentiation Fates
08:07

Stencil Micropatterning of Human Pluripotent Stem Cells for Probing Spatial Organization of Differentiation Fates

Published on: June 17, 2016

9.0K

Area of Science:

  • Stem cell biology
  • Regenerative medicine
  • Space biology

Background:

  • Stem cells are fundamental to organism development and tissue repair.
  • Mechanical forces, including gravity, influence stem cell fate.
  • Microgravity affects human physiology, partly due to altered stem cell behavior.

Approach:

  • This review synthesizes current research on microgravity's impact on stem cells.
  • Focuses on how microgravity influences stem cell differentiation pathways.

Key Points:

  • Microgravity alters stem cell differentiation processes.
  • These changes have implications for tissue regeneration.
  • Understanding microgravity effects is vital for regenerative medicine.

Conclusions:

  • Microgravity poses unique challenges and opportunities for stem cell research.
  • Further investigation is needed to harness stem cells in space environments.
  • Findings can inform the development of novel regenerative therapies.