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Behçet's syndrome in pregnancy.

Marcus Martineau1, Dorian O Haskard2, Catherine Nelson-Piercy3

  • 1Guy's & St Thomas' Foundation Trust , Westminster Bridge Road, London SE1 7EH.

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|September 2, 2016
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Summary

Behçet's syndrome (BS) rarely occurs during pregnancy but generally does not harm outcomes. Many BS medications are safe for pregnant and breastfeeding individuals, though some require avoidance.

Keywords:
drugs (medication)high-risk pregnancyrheumatology

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Area of Science:

  • Rheumatology
  • Obstetrics
  • Immunology

Background:

  • Behçet's syndrome (BS) is a rare systemic inflammatory disease affecting young adults.
  • Characterized by oral/genital ulcers, uveitis, and arthritis, BS typically impacts the third and fourth decades of life.

Purpose of the Study:

  • To review the impact of Behçet's syndrome on pregnancy outcomes.
  • To assess the safety of common Behçet's syndrome treatments during pregnancy and breastfeeding.

Main Methods:

  • Literature review of studies on Behçet's syndrome in pregnancy.
  • Analysis of drug safety profiles for immunosuppressants and biologics used in BS management.

Main Results:

  • Behçet's syndrome typically shows improvement during pregnancy, though its course can be unpredictable.
  • Corticosteroids, azathioprine, calcineurin inhibitors, and colchicine are generally considered safe for use during pregnancy and breastfeeding.
  • Experience with biologics in pregnancy is growing.

Conclusions:

  • Behçet's syndrome generally has a favorable prognosis in pregnancy with appropriate management.
  • Certain medications, including methotrexate, mycophenolate mofetil, thalidomide, cyclophosphamide, and chlorambucil, should be avoided in pregnant or planning-to-be-pregnant individuals.
  • Close monitoring and individualized treatment plans are essential for managing Behçet's syndrome during pregnancy.