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Ten questions on prosthetic shoulder infection
Elizabeth M Pinder1, Joshua Cy Ong1, R Stephen Bale1
1Upper Limb Unit, Wrightington Hospital, Wigan, Lancashire, UK.
Abstract:
Prosthetic shoulder infection can cause significant morbidity secondary to pain and stiffness. Symptoms may be present for years before diagnosis because clinical signs are often absent and inflammatory markers may be normal. An emerging common culprit, Propionibacterium acnes, is hard to culture and so prolonged incubation is necessary. A negative culture result does not always exclude infection and new synovial fluid biochemical markers such as α defensin are less sensitive than for lower limb arthroplasty. A structured approach is necessary when assessing patients for prosthetic shoulder joint infection. This includes history, examination, serum inflammatory markers, plain radiology and aspiration and/or biopsy. A classification for the likelihood of prosthetic shoulder infection has been described based on culture, pre-operative and intra-operative findings. Treatment options include antibiotic suppression, debridement with component retention, one-stage revision, two-stage revision and excision arthroplasty. Revision arthroplasty is associated with the best outcomes.
Insights
Diagnosing prosthetic shoulder joint infections can be challenging due to subtle symptoms and normal inflammatory markers. Revision arthroplasty offers the best outcomes for these complex cases.
Area of Science:
- Orthopedic Surgery
- Infectious Diseases
- Biochemistry
Background:
- Prosthetic shoulder joint infections lead to significant pain and stiffness, impacting patient morbidity.
- Diagnosis is often delayed due to absent clinical signs and normal inflammatory markers.
- Propionibacterium acnes, a common pathogen, requires prolonged incubation for culture, and newer markers lack sensitivity.
Purpose of the Study:
- To outline a structured approach for assessing prosthetic shoulder joint infections.
- To review diagnostic challenges and emerging markers.
- To discuss available treatment options and their associated outcomes.
Main Methods:
- Comprehensive patient assessment including history, physical examination, and serum inflammatory markers.
- Radiological evaluation and aspiration/biopsy for microbiological and biochemical analysis.
- Application of a classification system based on culture, and pre-operative/intra-operative findings.
Main Results:
- A structured diagnostic approach is essential for accurate prosthetic shoulder infection assessment.
- Challenges in culturing Propionibacterium acnes and limitations of current biochemical markers are highlighted.
- A classification system aids in determining infection likelihood.
Conclusions:
- Effective management of prosthetic shoulder infections requires a systematic diagnostic strategy.
- Treatment options range from conservative measures to complex revisions.
- Revision arthroplasty is associated with the most favorable patient outcomes.
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