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Decreased Body Temperature01:29

Decreased Body Temperature

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A decreased body temperature can occur in patients with hypothermia and frostbite. Heat loss with extended cold exposure overpowers the body's ability to create heat, resulting in hypothermia. Core temperature readings help classify hypothermia. Mild hypothermia is temperatures between 32 °C (89.6 °F) and 35°C (95 °F) and is caused by impaired thermoregulation. Moderate hypothermia is temperatures between 28 C (82.4 °F) and 32 °C (89.6 °F) caused by...
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Factors Affecting Lethal Isotherms During Cryoablation Procedures.

Andrew C Rau1, Ryan Siskey1, Jorge A Ochoa2

  • 1Exponent, Inc., 3440 Market Street, Suite 600, Philadelphia, PA 19104, United States.

The Open Biomedical Engineering Journal
|September 2, 2016
PubMed
Summary
This summary is machine-generated.

Probe selection is key for effective renal cryoablation. Different cryoprobe manufacturers and sizes significantly impact lethal isotherm size, more so than pressure or freeze duration adjustments.

Keywords:
CryoablationIn vitro gelatin modelLethal IsothermsProbesrenal tumors

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Area of Science:

  • Medical Devices
  • Oncology
  • Surgical Technology

Background:

  • Achieving adequate cell death in renal tumor cryoablation requires precise control over lethal isotherm size.
  • Surgeons must optimize probe selection (type, size, location, number) and operating parameters for effective treatment.
  • Understanding factors influencing isotherm dimensions is critical for successful cryoablation outcomes.

Purpose of the Study:

  • To investigate how cryoprobe type, operating pressure, and clinical method influence isotherm sizes in an in vitro gelatin model.
  • To compare the impact of different cryoprobe manufacturers on isotherm dimensions.
  • To evaluate the effect of procedural variations on the resulting freeze zones.

Main Methods:

  • Utilized four cryoprobes from two manufacturers in an in vitro gelatin model.
  • Conducted freeze procedures to compare the sizes of constant temperature zones (isotherms).
  • Studied the effects of clinically adjustable parameters like operating pressure and freeze protocols (single vs. multiple freeze cycles).

Main Results:

  • Significant differences in isotherm sizes (0 °C, -20 °C, -40 °C) were observed between probes from different manufacturers, even when similarly sized.
  • Variations in operating pressure showed less impact on isotherm size compared to probe manufacturer differences.
  • Multiple freeze procedures did not consistently yield statistically significant differences in isotherm sizes compared to single freeze procedures.

Conclusions:

  • Cryoprobe manufacturer and probe size are critical determinants of renal cryoablation kill zones.
  • Procedural adjustments, such as operating pressure and freeze duration, appear less influential than initial probe selection.
  • This highlights the importance of careful cryoprobe selection for optimizing therapeutic outcomes in renal tumor cryoablation.