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Selective Serotonin-norepinephrine Reuptake Inhibitors-induced Takotsubo Cardiomyopathy
Rahul Vasudev1, Upamanyu Rampal2, Hiten Patel2
1Department of Internal Medicine, New York Medical College, St Joseph's Regional Medical Center, New Jersey, USA.
Context:
Takotsubo translates to "octopus pot" in Japanese. Takotsubo cardiomyopathy (TTC) is characterized by a transient regional systolic dysfunction of the left ventricle. Catecholamine excess is the one most studied and favored theories explaining the pathophysiology of TTC.
Case Report:
We present the case of a 52-year-old Hispanic female admitted for venlafaxine-induced TTC with a review literature on all the cases of Serotonin-norepinephrine reuptake inhibitors (SNRI)-associated TTC published so far.
Conclusion:
SNRI inhibit the reuptake of catecholamines into the presynaptic neuron, resulting in a net gain in the concentration of epinephrine and serotonin in the neuronal synapses and causing iatrogenic catecholamine excess, ultimately leading to TTC.
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