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Updated: Mar 15, 2026

Field-Based Thermal Physiology Assay: Cold Shock Recovery under Ambient Conditions
Published on: March 9, 2021
Beyond the classic thermoneutral zone: Including thermal comfort
Boris Rm Kingma1, Arjan Jh Frijns2, Lisje Schellen3
1Department of Human Biology; NUTRIM School for Nutrition, Toxicology and Metabolism of Maastricht University Medical Center+; Maastricht, The Netherlands; Department of Mechanical Engineering; Eindhoven University of Technology; Eindhoven, The Netherlands.
The thermoneutral zone definition may need revision. Biophysical modeling reveals core and skin temperatures, not just ambient temperature, dictate thermal balance, potentially requiring behavioral changes before this zone is breached.
Area of Science:
- Human physiology
- Biophysics
- Environmental health
Background:
- The thermoneutral zone (TNZ) is defined by ambient temperatures allowing core temperature regulation via dry heat loss.
- Maintaining core temperature requires balancing metabolic heat production with heat loss to the environment.
Purpose of the Study:
- To investigate combinations of core and skin temperatures satisfying TNZ biophysical requirements in humans.
- To analyze the impact of insulation changes and thermal comfort on the TNZ.
- To re-evaluate the definition of the thermoneutral zone based on biophysical principles.
Main Methods:
- Development of a biophysical model to calculate human body heat transport.
- The model accounts for metabolic heat production, tissue insulation, and blood flow distribution.
- Heat transport is equated to heat loss to the environment under varying thermal conditions.
Main Results:
- The steady-state ambient temperature range of the TNZ does not inherently guarantee thermal balance at basal metabolic rate.
- Specific combinations of core, skin, and ambient temperatures may necessitate increased heat production or loss.
- The ambient temperature range for thermal comfort is narrower than the TNZ.
Conclusions:
- The current definition of the thermoneutral zone may require reformulation.
- Thermal behavior might be initiated prior to reaching TNZ boundaries due to thermal comfort considerations.
- Biophysical modeling provides a more nuanced understanding of human thermal regulation.
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