Related Experiment Video
Updated: Mar 15, 2026
05:01
Murine Model of Controlled Cortical Impact for the Induction of Traumatic Brain Injury
Published on: August 16, 2019
11.3K
Quality of the Development of Traumatic Brain Injury Clinical Practice Guidelines: A Systematic Review
Anjni Patel1, Mateus Mazorra Coelho Vieira2, John Abraham1
1Division of Emergency Medicine, Department of Surgery, Duke University Medical Center, Durham, North Carolina, United States of America.
Plos One
|September 2, 2016
Summary
Clinical Practice Guidelines for traumatic brain injury (TBI) are scarce in low-resource settings. This review found most TBI guidelines are from high-income countries and lack applicability for LMICs, highlighting a critical gap in global TBI management.
Area of Science:
- Neuroscience
- Public Health
- Clinical Practice Guidelines
Background:
- Traumatic brain injury (TBI) presents a growing global health challenge, with increasing incidence in low and middle-income countries (LMICs).
- Existing Clinical Practice Guidelines (CPGs) for acute TBI management often lack applicability in resource-limited settings.
Purpose of the Study:
- To systematically review and assess the quality of existing CPGs for acute TBI management.
- To identify CPGs suitable for implementation in resource-limited settings.
- To inform the development of a standardized CPG for acute TBI in LMICs.
Main Methods:
- Systematic review of CPGs for acute TBI (less than 24 hours post-injury) published between April 2013 and December 2015.
- Searched MEDLINE, EMBASE, Google Scholar, and Duke University Medical Center Library Guidelines.
- Assessed CPG quality using the AGREE II instrument by five independent reviewers.
Main Results:
- Evaluated 24 CPGs, with 23 originating from high-income countries (HICs) and only 1 from an LMIC.
- Top-scoring CPGs (NIHCE, NZ, SIGN) demonstrated high quality in clarity, scope, and rigor but were developed in HICs.
- The single LMIC CPG scored lower than those from HICs, indicating limited applicability.
Conclusions:
- Most available acute TBI CPGs are developed in HICs and possess limited utility for LMICs.
- Key areas for improvement in CPG development for resource-limited settings include stakeholder involvement, applicability, and editorial independence.
- There is a critical need for developing and adapting TBI CPGs tailored to the specific challenges and resource constraints of LMICs.
