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Relationship between premature ejaculation and depression: A PRISMA-compliant systematic review and meta-analysis
Yue Xia1, Juanjuan Li, Guang Shan
1Department of Urology, Renmin Hospital of Wuhan University, Wuhan, Hubei Department of Breast and Thyroid Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei Department of Urology, Longjiang Hospital of Shunde District in Foshan City Department of Physiology of Southern Medical University, Guangzhou, Guangdong Department of Infertility and Sexual Medicine, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou Department of Urology & Andrology, Minimally Invasive Surgery Center, Guangdong Key Laboratory of Urology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.
Depression significantly increases the risk of premature ejaculation (PE), the most common male sexual dysfunction. Further research is needed to understand this association and guide effective treatments.
Area of Science:
- Male Sexual Health
- Mental Health and Psychiatry
- Epidemiology
Background:
- Premature ejaculation (PE) is the most common male sexual dysfunction.
- Epidemiological data on the link between PE and depression risk are inconsistent.
- This study investigates the association between depression and the risk of developing PE.
Purpose of the Study:
- To examine the potential association between depression and the risk of premature ejaculation.
- To synthesize existing epidemiological evidence on this relationship.
Main Methods:
- A systematic literature search was conducted on PubMed, Embase, and Cochrane Library up to June 2014.
- Observational epidemiological studies reporting risk estimates for PE associated with depression were included.
- A meta-analysis pooled odds ratios (ORs) from eight trials involving 18,035 participants, using random or fixed effects models.
Main Results:
- A statistically significant association was found between depression and an increased risk of PE (OR = 1.63, 95% CI: 1.42-1.87).
- No significant between-study heterogeneity was detected (P = 0.623, I² = 0.0%).
- The association remained consistent across various subgroup analyses, including geographical area, study design, and control for confounders.
Conclusions:
- Depression is significantly associated with an elevated risk of premature ejaculation.
- The severity of depression and PE could not be determined due to data limitations.
- Further prospective studies are recommended to confirm the association and determine optimal treatment strategies.
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