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Changes in the Composition of Adiponectin Fractions over a 3-Year Period in Children: A Population-Based Cohort Study
Rimei Nishimura1,2, Hironari Sano1, Takako Shirasawa3
11 Division of Diabetes, Metabolism, and Endocrinology, Department of Internal Medicine, Jikei University School of Medicine , Tokyo, Japan .
Insights
This study found that high-molecular weight adiponectin (HAD) levels significantly decreased in children over 3 years, with HAD changes strongly correlating with BMI changes. This highlights HAD
Area of Science:
- Pediatric Endocrinology
- Metabolic Health Research
- Adipokine Fraction Analysis
Background:
- Limited data exists on adiponectin fraction changes in children.
- Understanding these changes is crucial for metabolic health insights.
Purpose of the Study:
- To investigate alterations in adiponectin fractions within a prospective pediatric cohort.
- To analyze the relationship between adiponectin fractions and BMI over time.
Main Methods:
- A 3-year prospective study of 358 Japanese fourth graders (9-10 years old).
- Measurements included Body Mass Index (BMI) and adiponectin fractions (total, high-molecular weight, medium-molecular weight, low-molecular weight) at baseline and follow-up.
- Statistical analysis to assess changes and correlations.
Main Results:
- No significant change in total adiponectin (TAD) was observed.
- High-molecular weight adiponectin (HAD) significantly decreased in both boys and girls.
- Significant negative correlations were found between BMI changes and TAD/HAD changes over 3 years.
Conclusions:
- High-molecular weight adiponectin (HAD) demonstrated the strongest correlation with baseline and follow-up values.
- Changes in HAD showed the most robust correlation with concurrent changes in BMI over the 3-year study period.
Background:
Little information is available regarding changes in adiponectin fractions. The objective of this study was to examine changes in the composition of differing adiponectin fractions using a population-based, prospective pediatric cohort.
Methods:
A total of 358 fourth graders (9-10 years old) from Ina town in Saitama, Japan, were followed up for 3 years. BMI and total adiponectin (TAD), high-molecular weight adiponectin (HAD), medium-molecular weight adiponectin, and low-molecular weight adiponectin levels were measured in these subjects at baseline and at the end of the follow-up.
Results:
Of the fourth graders participating in the study, 326 (172 boys and 154 girls; follow-up rate, 91.1%) became available for follow-up. No significant changes were observed in TAD values after 3 years. HAD values were significantly decreased in both the boys (2.4 to 2.2 μg/mL: p < 0.001) and girls (3.1 to 2.7 μg/mL: p = 0.005). All values in the parameters examined at baseline and after 3 years were significantly correlated. A negative correlation was found between the ratios of follow-up compared to baseline values for BMI and those for TAD (boys, r = -0.322, p < 0.001; girls, r = -0.433, p < 0.001) as well as those for HAD (boys, r = -0.353, p < 0.001; girls, r = -0.351, p < 0.001).
Conclusions:
HAD had the most robust correlation between its values at baseline and those after 3 years in both boys and girls. The changes in HAD also had the most robust correlation between the changes in BMI in 3 years.
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