Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Allergic Reactions02:06

Allergic Reactions

33.3K
Overview
33.3K
Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

111
Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin,...
111
Accessory Structures of the Skin: Sweat Glands01:20

Accessory Structures of the Skin: Sweat Glands

4.5K
Sweat glands or sudoriferous glands are one of the important accessory structures of the skin. They are small, coiled tubular structures located in the dermis, the middle layer of the skin. Sweat glands are responsible for producing and secreting sweat, a watery fluid that helps regulate body temperature and excrete waste products.
Sweat glands are classified as merocrine glands; that is, the secretions are excreted by exocytosis through a duct without affecting the cells of the gland. There...
4.5K
Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

91
Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial...
91
Allergic Drug Reactions01:27

Allergic Drug Reactions

1.6K
Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
1.6K
Hypersensitivities01:30

Hypersensitivities

8.1K
Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
8.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Safety of remibrutinib in chronic spontaneous urticaria: a pooled analysis of REMIX-1 and REMIX-2 trials.

The journal of allergy and clinical immunology. In practice·2026
Same author

FXII Frameshift Variant Does Not Cause Hereditary Angioedema with Normal C1 Inhibitor.

Journal of clinical immunology·2026
Same author

The 2025 WAO Guidelines for the classification, diagnosis, and treatment of hereditary angioedema, with consideration of worldwide disparities.

The World Allergy Organization journal·2026
Same author

Arerugi = [Allergy]·2026
Same author

Intradermal injection of human sweat enhances production of specific IgG against antigens solved in the sweat.

Asia Pacific allergy·2026
Same author

Factors Associated with Symptomatic Dermographism: Findings from the UCARE PREVALENCE-D Study.

American journal of clinical dermatology·2026

Related Experiment Video

Updated: Mar 15, 2026

A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma
06:34

A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma

Published on: June 4, 2017

10.5K

Sweat Allergy.

Takaaki Hiragun, Michihiro Hide

    Current Problems in Dermatology
    |September 2, 2016
    PubMed
    Summary
    This summary is machine-generated.

    Researchers identified a key allergen in sweat, MGL_1304 from Malassezia globosa, which triggers histamine release in patients with atopic dermatitis (AD) and cholinergic urticaria (CholU). This finding may lead to new treatments for sweat allergy.

    More Related Videos

    A Detailed Protocol for Perspiration Monitoring Using a Novel, Small, Wireless Device
    05:32

    A Detailed Protocol for Perspiration Monitoring Using a Novel, Small, Wireless Device

    Published on: November 24, 2016

    8.3K
    Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber
    08:47

    Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber

    Published on: March 3, 2023

    3.1K

    Related Experiment Videos

    Last Updated: Mar 15, 2026

    A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma
    06:34

    A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma

    Published on: June 4, 2017

    10.5K
    A Detailed Protocol for Perspiration Monitoring Using a Novel, Small, Wireless Device
    05:32

    A Detailed Protocol for Perspiration Monitoring Using a Novel, Small, Wireless Device

    Published on: November 24, 2016

    8.3K
    Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber
    08:47

    Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber

    Published on: March 3, 2023

    3.1K

    Area of Science:

    • Dermatology
    • Allergology
    • Microbiology

    Background:

    • Sweat is a known trigger for atopic dermatitis (AD) and cholinergic urticaria (CholU).
    • Previous research suggested tannic acid and showering could alleviate AD symptoms by affecting sweat antigens.

    Purpose of the Study:

    • To identify the specific sweat antigen responsible for histamine release in AD and CholU patients.
    • To investigate the role of Malassezia globosa-derived antigens in sweat-induced allergic reactions.

    Main Methods:

    • Identification of MGL_1304 as a major histamine-releasing antigen secreted by Malassezia globosa in human sweat.
    • Quantification of MGL_1304 protein in sweat.
    • Measurement of histamine release from basophils of AD and CholU patients.
    • Assay of serum anti-MGL_1304 IgE levels in patients and controls.

    Main Results:

    • MGL_1304, a 17-kDa protein, was identified as a primary histamine-releasing antigen in sweat.
    • MGL_1304 demonstrated high histamine-release activity from basophils of AD and CholU patients.
    • Serum IgE levels against MGL_1304 were significantly elevated in patients with AD and CholU compared to healthy individuals.

    Conclusions:

    • MGL_1304 is a major allergen in sweat contributing to atopic dermatitis and cholinergic urticaria.
    • Elevated IgE against MGL_1304 confirms its role in sweat allergy.
    • Desensitization therapy with MGL_1304 or related compounds shows potential for treating intractable cholinergic urticaria due to sweat allergy.