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Updated: Mar 15, 2026

In Silico Clinical Trials for Cardiovascular Disease
Published on: May 27, 2022
Evolution of Cardiac Biomodels from Computational to Therapeutics
Alwin Kumar Rathinam1, Raja Amin Raja Mokhtar1
1Heartstrings Research & Innovation and 2Cardiovascular and Thoracic Surgery Unit, Department of Surgery, University of Malaya, Kuala Lumpur, Malaysia.
Abstract:
Biomodeling the human anatomy in exact structure and size is an exciting field of medical science. Utilizing medical data from various medical imaging topography, the data of an anatomical structure can be extracted and converted into a three-dimensional virtual biomodel; thereafter a physical biomodel can be generated utilizing rapid prototyping machines. Here, we have reviewed the utilization of this technology and have provided some guidelines to develop biomodels of cardiac structures. Cardiac biomodels provide insights for cardiothoracic surgeons, cardiologists, and patients alike. Additionally, the technology may have future usability for tissue engineering, robotic surgery, or routine hospital usage as a diagnostic and therapeutic tool for cardiovascular diseases (CVD). Given the broad areas of application of cardiac biomodels, attention should be given to further research and development of their potential.
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