Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Deacetylation of PRDX1 contributes to alleviating acute liver injury through Dihydromyricetin-mediated SIRT1 upregulation.

Phytomedicine : international journal of phytotherapy and phytopharmacology·2026
Same author

Crystallographic Study Reveals a Cryptic Allosteric Site of FBPase by Sulfonylurea Inhibitors toward T2DM Treatment.

Journal of medicinal chemistry·2026
Same author

pH Regulates Ion Dynamics in Carboxylated Mixed Conductors.

Chemistry of materials : a publication of the American Chemical Society·2026
Same author

Multi-omics integration identifies ganoderic acid A as a TNFα inhibitor for treating sepsis-related liver injury.

Frontiers in pharmacology·2026
Same author

Moronic acid alleviates non-alcoholic fatty liver disease and fibrosis through PPARs-mediated lipidomic reprogramming.

Phytomedicine : international journal of phytotherapy and phytopharmacology·2025
Same author

Organic Mixed Ionic-Electronic Conductors for Organic Electrochemical Transistors: Sidechain Structure Influences Ion Uptake and Functional Performance.

Chemphyschem : a European journal of chemical physics and physical chemistry·2025

Related Experiment Video

Updated: Mar 15, 2026

Surface Enhanced Raman Spectroscopy Detection of Biomolecules Using EBL Fabricated Nanostructured Substrates
11:44

Surface Enhanced Raman Spectroscopy Detection of Biomolecules Using EBL Fabricated Nanostructured Substrates

Published on: March 20, 2015

21.6K

Three-Dimensional Clustered Nanostructures for Microfluidic Surface-Enhanced Raman Detection.

Gang Wang1,2, Kerui Li1, Francis J Purcell

  • 1State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University , Shanghai 201602, People's Republic of China.

ACS Applied Materials & Interfaces
|September 2, 2016
PubMed
Summary
This summary is machine-generated.

Researchers developed a new method to create 3D nanostructures for microfluidic surface-enhanced Raman spectroscopy (SERS) systems. This innovation enables sensitive detection of pollutants and biomolecules, advancing environmental and health monitoring.

Keywords:
SERS detectionbiomolecule detectionclustered nanostructuresfluid constructionmicrofluidic technology

More Related Videos

Author Spotlight: Advancements and Applications in Nanoparticle Synthesis Through Laser Ablation in Liquids
06:15

Author Spotlight: Advancements and Applications in Nanoparticle Synthesis Through Laser Ablation in Liquids

Published on: June 16, 2023

2.7K
Fabricating a UV-Vis and Raman Spectroscopy Immunoassay Platform
09:02

Fabricating a UV-Vis and Raman Spectroscopy Immunoassay Platform

Published on: November 10, 2016

10.8K

Related Experiment Videos

Last Updated: Mar 15, 2026

Surface Enhanced Raman Spectroscopy Detection of Biomolecules Using EBL Fabricated Nanostructured Substrates
11:44

Surface Enhanced Raman Spectroscopy Detection of Biomolecules Using EBL Fabricated Nanostructured Substrates

Published on: March 20, 2015

21.6K
Author Spotlight: Advancements and Applications in Nanoparticle Synthesis Through Laser Ablation in Liquids
06:15

Author Spotlight: Advancements and Applications in Nanoparticle Synthesis Through Laser Ablation in Liquids

Published on: June 16, 2023

2.7K
Fabricating a UV-Vis and Raman Spectroscopy Immunoassay Platform
09:02

Fabricating a UV-Vis and Raman Spectroscopy Immunoassay Platform

Published on: November 10, 2016

10.8K

Area of Science:

  • Materials Science
  • Nanotechnology
  • Analytical Chemistry

Background:

  • Surface-enhanced Raman spectroscopy (SERS) requires specialized nanostructured substrates for sensitive detection.
  • Existing fabrication methods can be complex and limit the integration of SERS into microfluidic devices.
  • The development of novel nanostructures is crucial for advancing real-time analytical systems.

Purpose of the Study:

  • To present a fluid-construction strategy for fabricating 3D ZnO@ZnS-Ag nanostructures within microchannels.
  • To develop an integrated microfluidic SERS system with enhanced detection capabilities.
  • To demonstrate the efficacy of these nanostructures for detecting various analytes.

Main Methods:

  • Fabrication of 3D ZnO@ZnS-Ag nanostructures using a fluid-construction strategy within microchannels.
  • Finite-difference time-domain (FDTD) analysis to understand hot spot formation in the 3D clustered geometry.
  • Evaluation of SERS performance using 4-mercaptobenzoic acid (4-MBA) and Rhodamine 6G (R6G) as target analytes.
  • Testing the system for the detection of a nerve agent and a biomolecule.

Main Results:

  • Facile construction of nanostructured substrates with numerous integrated hot spots supporting SERS activity.
  • FDTD analysis confirmed that the 3D clustered geometry enhances hot spot formation.
  • Demonstrated high sensitivity and good recyclability in detecting organic pollutants (4-MBA, R6G).
  • Successful detection of a representative nerve agent and a biomolecule using the developed system.

Conclusions:

  • The fluid-construction approach provides an effective materials and process strategy for fabricating SERS-active nanostructures.
  • The integrated microfluidic SERS system shows promise for online detection of organic pollutants and real-time monitoring.
  • This technology has potential applications in environmental hazard observation and personal health monitoring.