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Using Human Differentially Expressed Gene Lists to Perform Downstream Pathway Enrichment Analysis and Target Prioritization

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SPAI: an interactive platform for indel analysis.

Mohammad Shabbir Hasan¹, Liqing Zhang²

¹Department of Computer Science, Virginia Tech, Blacksburg, VA, 24061, USA.

|September 3, 2016

Summary

This summary is machine-generated.

SPAI is a new platform that simplifies the analysis of insertions and deletions (indels) in the human genome. This graphical tool allows researchers to run indel calling tools without needing computer science expertise.

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Area of Science:

Genomics
Bioinformatics

Background:

Insertions and Deletions (Indels) are the most common human genome structural variations.
Indels contribute to genetic diversity and disease, making their assessment crucial.
Existing indel calling tools require command-line expertise, posing a challenge for non-Computer Science researchers.

Purpose of the Study:

To introduce SPAI (Single Platform for Analyzing Indels), an interactive platform for indel analysis.
To provide a user-friendly interface for researchers without a Computer Science background.

Main Methods:

Developed SPAI as a Graphical User Interface (GUI) tool.
SPAI is implemented in Java and tested on the Linux operating system.

Main Results:

SPAI enables users to execute multiple popular indel calling tools.
Facilitates various analyses on indel calling results through an intuitive interface.
Eliminates the need for command-line programming for indel analysis.

Conclusions:

SPAI lowers the barrier to entry for human genome indel analysis.
Empowers researchers from diverse backgrounds to investigate genetic variations and associated diseases.