Related Experiment Videos
Chronic recurrent multifocal osteomyelitis in association with pyoderma gangraenosum
Matthias Christian Wurm1, Ines Brecht2, Michael Lell3
1Department of Oral and Maxillofacial Surgery, University of Erlangen-Nürnberg, Glückstrasse 11, 91054, Erlangen, Germany. Matthias.Wurm@uk-erlangen.de.
BMC Oral Health
|September 3, 2016
Summary
Chronic recurrent multifocal osteomyelitis (CRMO), a rare inflammatory bone disorder, can manifest unusually. This case highlights CRMO affecting the mandible, presenting a diagnostic challenge due to its rarity.
Area of Science:
- Pediatric Rheumatology
- Skeletal Dysplasias
- Inflammatory Disorders
Background:
- Chronic recurrent multifocal osteomyelitis (CRMO) is a rare, acquired inflammatory skeletal disorder of unknown origin.
- CRMO primarily affects children and young adults, predominantly females, characterized by relapsing-remitting courses.
- Typically, CRMO affects long bones' metaphysis, presenting as painful swellings.
Observation:
- A 14-year-old female presented with escalating neck pain and facial swelling, recurring quarterly for four years.
- Clinical examination revealed moderately elevated C-reactive protein (CRP) and an increased blood sedimentation rate (BSR).
- Radiographic imaging identified a bone alteration in the left mandibular region.
Findings:
- The case report details an unusual presentation of CRMO involving the mandible.
- This mandibular CRMO was associated with pyoderma gangraenosum.
- Diagnostic investigations confirmed CRMO as the cause of the mandibular lesion.
Implications:
- Rare diseases can present with exceptionally uncommon symptoms, posing significant diagnostic challenges.
- This case underscores the importance of considering CRMO in pediatric patients with unexplained mandibular lesions and inflammatory markers.
- Increased awareness of atypical CRMO presentations is crucial for timely diagnosis and management.
Related Concept Videos
01:28Acute Pyelonephritis II: Diagnostic Studies and Management
594
Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
594
01:27Acute Pyelonephritis I: Introduction
990
Pyelonephritis is a bacterial infection that primarily affects the renal parenchyma and collecting system, including the renal pelvis, tubules, and interstitial tissue of one or both kidneys. It can be classified as either acute—a sudden, severe infection—or chronic, which refers to long-term or recurrent kidney infections.The primary cause of acute pyelonephritis (APN) is bacterial infection, with Escherichia coli accounting for approximately 70-80% of cases. Other bacteria, such...
990
01:23Skin Diseases and Disorders
6.0K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
6.0K
01:29Chronic Pancreatitis II: Collaborative Care
456
The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
Assessment:
456
01:24Chronic Pancreatitis I: Introduction
842
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
842
01:23Gastritis III: Clinical Manifestations and Management
1.6K
The clinical manifestations of gastritis can vary depending on the cause and type of gastritis, but some common symptoms may include the following.
Clinical manifestations of acute gastritis
The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...
Clinical manifestations of acute gastritis
The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...
1.6K