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Genetics and Genomics of Coronary Artery Disease

Milos Pjanic1, Clint L Miller1, Robert Wirka1

  • 1Department of Medicine, Division of Cardiovascular Medicine, Cardiovascular Institute, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA, 94305-5233, USA.

Current Cardiology Reports
|September 3, 2016
PubMed

Insights

Coronary artery disease, a leading cause of death, involves plaque buildup and inflammation. Genetic factors and gene-environment interactions significantly influence disease risk and progression.

Area of Science:

  • Cardiovascular Science
  • Genetics and Genomics

Background:

  • Coronary artery disease (CAD) is a primary global cause of mortality.
  • Plaque formation, inflammation, and vessel narrowing characterize CAD, leading to heart attacks.
  • While environmental factors like high LDL-cholesterol, diabetes, and hypertension are known risks, genetic predisposition and gene-environment interactions play a critical role in disease development.

Purpose of the Study:

  • To provide a comprehensive overview of current genetic and genomics research in coronary artery disease.
  • To summarize various genetic and genomics assays and approaches utilized in CAD research.

Main Methods:

  • Review of current genetic and genomics assays.
  • Summary of approaches applied to coronary artery disease research.

Main Results:

  • Significant advancements have been made in genetics and genomics concerning CAD.
  • Genomics is a rapidly evolving field with potential for future breakthroughs in understanding CAD.

Conclusions:

  • Understanding the genetic and genomic underpinnings of CAD is crucial for advancing research.
  • Various genetic and genomics methodologies are being applied to study CAD, with ongoing potential for discovery.

Keywords:
Coronary artery diseaseEpigeneticsGWASGeneticsGenomicsTranscriptomics

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