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Neurenteric Cyst or Neuroendodermal Cyst? Immunohistochemical Study and Pathogenesis
Chun-Ting Chen1, Hung-Yi Lai1, Shih-Ming Jung2
1Department of Neurosurgery, Chang Gung Memorial Hospital and Chang Gung University at Linko, Taiwan, Republic of China.
World Neurosurgery
|September 3, 2016
Summary
Neurenteric cysts originate from endodermal cells that migrate along the neuroectoderm. Immunohistochemical analysis reveals resemblance to respiratory and gastric tissues, suggesting multipotent cell origin.
Area of Science:
- Neuroscience
- Developmental Biology
- Pathology
Background:
- Neurenteric cysts are rare central nervous system lesions of endodermal origin.
- Their pathogenesis remains unclear due to infrequent occurrences.
Purpose of the Study:
- To investigate the pathogenesis of neurenteric cysts.
- To analyze the cell types and origin of neurenteric cysts through immunohistochemistry.
Main Methods:
- Retrospective review of 10 surgically treated neurenteric cyst cases (1995-2015).
- Analysis of clinical, radiologic, operative, and pathologic findings.
- Immunohistochemical staining to determine cell type and origin.
Main Results:
- Identified pseudostratified-ciliated, goblet-columnar, and simple cuboidal cells.
- All cases showed cytokeratin 7 positivity and negativity for other markers (CK20, CDX2, MUC2, TTF1, hCG, PLAP, CD31).
- Goblet-columnar cells expressed Mucin 5AC; recurrence was associated with this component.
Conclusions:
- Postulated origin from multipotent endodermal cells migrating along the neuroectoderm.
- Incomplete differentiation due to microenvironment suggested.
- Proposed 'neuroendodermal cysts' as a more precise term due to the neurenteric canal's role as a migration channel only.
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