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Ability and efficiency of an automatic analysis software to measure microvascular parameters
Andrea Carsetti1,2, Hollmann D Aya1, Silvia Pierantozzi1,2
1Department of Intensive Care Medicine, St George's University Hospitals NHS Foundation Trust, Blackshaw Road, London, SW17 0QT, UK.
Journal of Clinical Monitoring and Computing
|September 3, 2016
Summary
CytoCamTools (CC) software offers faster microcirculation analysis than Automated Vascular Analysis (AVA) software. While total vessel density (TVD) is comparable, perfused vessel density (PVD) and proportion of perfused vessels (PPV) are not interchangeable.
Area of Science:
- Cardiovascular Research
- Medical Imaging
- Intensive Care Medicine
Background:
- Offline microcirculation analysis is time-consuming and operator-dependent.
- Automated analysis tools aim to improve efficiency and objectivity.
- Assessing microvascular function is crucial in critical care settings.
Purpose of the Study:
- To evaluate the performance of CytoCamTools (CC) software for microvascular parameter measurement.
- To compare CC software with Automated Vascular Analysis (AVA) software in terms of accuracy and efficiency.
- To assess the interchangeability of microvascular parameters derived from both software.
Main Methods:
- Prospective enrollment of 22 cardiothoracic intensive care unit patients post-cardiac surgery.
- Analysis of sublingual microcirculatory videos using both AVA and CC software.
- Calculation of total vessel density (TVD), perfused vessel density (PVD), and proportion of perfused vessels (PPV).
- Comparison of blood flow indices: microvascular flow index (MFI) for AVA and averaged perfused speed indicator (APSI) for CC.
- Recording and comparison of analysis duration.
Main Results:
- Total vessel density (TVD) showed good correlation (r=0.74) and comparability between CC and AVA, with CC being significantly faster (median 2'42" vs 16'12").
- Perfused vessel density (PVD) was positively correlated (r=0.66) but showed significant bias and wide limits of agreement, indicating non-interchangeability.
- Proportion of perfused vessels (PPV) was significantly lower with CC software compared to AVA (median 81.65% vs 97.39%).
- Microvascular flow index (MFI) categories could not predict averaged perfused speed indicator (APSI) values.
Conclusions:
- CytoCamTools (CC) software provides a faster alternative for microcirculation analysis, with comparable total vessel density (TVD) to AVA.
- Perfused vessel density (PVD) and proportion of perfused vessels (PPV) measurements are not interchangeable between CC and AVA due to differing methodologies.
- The choice of software impacts microvascular flow assessment, necessitating careful consideration in clinical practice and research.
