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Peptide Bonds

Peptide Bonds

A peptide bond covalently attaches amino acids through a dehydration reaction. One amino acid's carboxyl group and another amino acid's amino group combine, releasing a water molecule. The resulting bond is the peptide bond. The products that such linkages form are peptides. As more amino acids join this growing chain, the resulting chain is a polypeptide. Each polypeptide has a free amino group at one end. This end has the N-terminal, or the amino-terminal, and the other end has a free...

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Related Experiment Video

Updated: Mar 15, 2026

Insights into the Interactions of Amino Acids and Peptides with Inorganic Materials Using Single-Molecule Force Spectroscopy

Insights into the Interactions of Amino Acids and Peptides with Inorganic Materials Using Single-Molecule Force Spectroscopy

Published on: March 6, 2017

Peptide Binding for Bio-Based Nanomaterials.

N M Bedford¹, C J Munro², M R Knecht²

¹National Institute of Standards and Technology, Boulder, CO, United States.

Methods in Enzymology

|September 3, 2016

Summary

This summary is machine-generated.

Peptide-capped nanoparticles offer sustainable material fabrication. Specific peptide sequences control nanoparticle surface structure, enhancing catalytic activity for chemical transformations.

Keywords:

Catalysis Nanoparticles Peptides Synthetic site-directed mutagenesis

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Last Updated: Mar 15, 2026

Insights into the Interactions of Amino Acids and Peptides with Inorganic Materials Using Single-Molecule Force Spectroscopy

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Published on: March 6, 2017

Study of Short Peptide Adsorption on Solution Dispersed Inorganic Nanoparticles Using Depletion Method

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Published on: April 11, 2020

A Tripeptide-Stabilized Nanoemulsion of Oleic Acid

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Published on: February 27, 2019

Area of Science:

Biomimetic materials science
Nanotechnology
Catalysis

Background:

Peptide-based strategies leverage biological methods for sustainable inorganic material fabrication.
Peptides with inorganic affinity are isolated from organisms or selected via techniques like phage display.
These peptides bind inorganic surfaces via noncovalent interactions, modifying them for enhanced properties.

Purpose of the Study:

To investigate the biological basis of peptide control over biomimetic nanoparticle catalytic activity.
To understand how peptide sequences influence nanoparticle surface structure and subsequent catalytic function.
To establish structure/function relationships in peptide-capped nanoparticles.

Main Methods:

Isolation and selection of peptides with inorganic affinity.
Fabrication of peptide-capped nanoparticles.
Site-directed mutagenesis studies to analyze localized peptide binding.
Atomic-resolution characterization of nanoparticle surface structure.
Correlation of structural features with catalytic activity.

Main Results:

Peptide binding modifies inorganic nanoparticle surfaces, incorporating disordered metal atoms.
Disordered surface metal atoms exhibit high catalytic activity in chemical transformations.
Specific peptide sequences influence nanoparticle surface structure.
Structure/function relationships between peptide sequence, surface structure, and catalytic activity were identified.

Conclusions:

Peptide-capped nanoparticles provide a tunable platform for developing highly active catalysts.
Understanding peptide-surface interactions is key to controlling nanoparticle catalytic performance.
This work establishes a framework for designing advanced catalytic nanomaterials through biomimetic approaches.