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What rheumatologists need to know about innate lymphocytes
Mark A Exley1,2,3, George C Tsokos4, Kingston H G Mills5
1Manchester Collaborative Centre for Inflammation Research (MCCIR), The University of Manchester, Grafton Street, Manchester M13 9NT, UK.
Nature Reviews. Rheumatology
|September 3, 2016
Summary
Innate lymphocytes play key roles in autoimmune diseases, contributing to tissue damage and responding to therapies. Certain innate lymphocyte subsets show promise as therapeutic targets for autoimmune conditions.
Area of Science:
- Immunology
- Rheumatology
- Autoimmunity
Background:
- Rheumatic diseases often stem from autoimmune processes.
- Innate lymphocytes, rapid responders, influence immune responses and tissue homeostasis.
- Evidence since 2010 highlights innate lymphocyte involvement in autoimmunity.
Purpose of the Study:
- To review innate lymphocyte subsets' characteristics and functions.
- To describe their roles in autoimmune diseases.
- To discuss their response to biologic therapies and potential as therapeutic targets.
Main Methods:
- Review of current literature on innate lymphocytes and autoimmunity.
- Analysis of innate lymphocyte roles in antigen-specific responses.
- Examination of cytotoxicity and tissue damage contributions.
Main Results:
- Innate lymphocytes are implicated in both initiating and maintaining autoimmune responses.
- Cytotoxicity of innate lymphocytes can lead to inflammatory tissue damage.
- Innate lymphocytes interact with and respond to biologic therapies.
Conclusions:
- Innate lymphocytes are crucial players in autoimmune pathogenesis.
- Specific innate lymphocyte subsets represent potential therapeutic targets for autoimmune diseases.
- Understanding innate lymphocyte function is key for developing novel treatments.
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