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Updated: Mar 15, 2026

Evaluation of Injury-induced Senescence and In Vivo Reprogramming in the Skeletal Muscle

Evaluation of Injury-induced Senescence and In Vivo Reprogramming in the Skeletal Muscle

Published on: October 26, 2017

Failed reinnervation in aging skeletal muscle.

Sudhakar Aare¹, Sally Spendiff¹, Madhusudanarao Vuda¹

¹Research Institute of the McGill University Health Centre, EM2.2232, RI MUHC, 1001 Decarie Blvd, Montreal, QC Canada H4A 3J1 ; McGill Research Centre for Physical Activity and Health, McGill University, Montreal, QC Canada.

Skeletal Muscle

|September 3, 2016

Summary

Aging muscle shows increased denervated fibers due to failed reinnervation. This failure may stem from a limited neurotrophin response, hindering axonal sprouting and contributing to muscle atrophy in older individuals.

Keywords:

Aging Denervation MicroRNA Muscle atrophy Neurotrophins Reinnervation Sarcopenia Skeletal muscle

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Area of Science:

Muscle physiology
Neuroscience
Aging research

Background:

Skeletal muscle accumulates denervated myofibers with age, accelerating muscle atrophy.
Understanding the mechanisms of failed reinnervation in aging muscle is crucial.

Purpose of the Study:

To test if aging-related denervated myofiber accumulation results from failed reinnervation.
To compare reinnervation capacity in aging rats and a mouse model of denervation.

Main Methods:

Examined muscle from young adult and very old rats.
Utilized a murine model of sporadic denervation (Sarco mouse).
Analyzed fiber-type grouping, endplate markers, and gene/miRNA expression related to denervation and reinnervation.

Main Results:

Aging rat and Sarco mouse muscles showed fiber-type grouping, indicating denervation/reinnervation cycles.
Very old rat muscle exhibited persistent denervation with upregulated denervation transcripts and increased rapsyn.
Aging muscle showed a limited neurotrophin response and elevated suppressive miRNAs, suggesting impaired axonal sprouting.

Conclusions:

Failed reinnervation contributes to denervated fiber accumulation in aging muscle.
Impaired neurotrophin response and axonal sprouting may exacerbate denervation in aging muscle.