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Updated: Mar 15, 2026

Mouse Kidney Transplantation: Models of Allograft Rejection
Published on: October 11, 2014
APOL1-Associated End-Stage Renal Disease in a Living Kidney Transplant Donor
N A Zwang1,2, A Shetty1, N Sustento-Reodica1
1Comprehensive Transplant Center, Northwestern University Feinberg School of Medicine, Chicago, IL.
Abstract:
Homozygosity for apolipoprotein-L1 (APOL1) risk variants has emerged as an important predictor of renal disease in individuals of African descent over the past several years. Additionally, these risk variants may be important predictors of renal allograft failure when present in a living or deceased donor. Currently, there is no universal recommendation for screening of potential donors. We present a case of end-stage renal disease with focal segmental glomerulosclerosis in a living donor 7 years following donor nephrectomy. Genetic assessment revealed homozygosity for the G1 high-risk APOL1 variant.
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