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Updated: Mar 15, 2026
Morphometric Analyses of Retinal Sections
Published on: February 19, 2012
Ratiometric analysis of in vivo retinal layer thicknesses in multiple sclerosis
Basanta Bhaduri1, Ryan M Nolan2, Ryan L Shelton2
1Indian Institute of Technology (Indian School of Mines) Dhanbad, Department of Applied Physics, Academic Complex, Dhanbad, Jharkhand 826004, IndiabUniversity of Illinois at Urbana-Champaign, Beckman Institute for Advanced Science and Technology, 405 North Mathews Avenue, Urbana, Illinois 61801, United StatescUniversity of Illinois at Urbana-Champaign, Department of Electrical and Computer Engineering, 619 South Wright Street, Champaign, Illinois 61820, United States.
Abstract:
We performed ratiometric analysis of retinal optical coherence tomography images for the first time in multiple sclerosis (MS) patients. The ratiometric analysis identified differences in several retinal layer thickness ratios in the cohort of MS subjects without a history of optic neuritis (ON) compared to healthy control (HC) subjects, and there was no difference in standard retinal nerve fiber layer thickness (RNFLT). The difference in such ratios between HC subjects and those with mild MS-disability, without a difference in RNFLT, further suggests the possibility of using layer ratiometric analysis for detecting early retinal changes in MS. Ratiometric analysis may be useful and potentially more sensitive for detecting disease changes in MS.
