Surface Plasmon Resonance-Based Fiber Optic Sensors Utilizing Molecular Imprinting

Area of Science:

• Analytical Chemistry
• Materials Science
• Biotechnology

Background:

• Molecular imprinting provides specific affinity for template molecules, crucial for selective analyte detection.
• Surface Plasmon Resonance (SPR) and Localized SPR (LSPR) offer sensitive, real-time detection capabilities.
• Optical fibers enhance SPR/LSPR sensors with miniaturization, remote sensing, and online monitoring.

Purpose of the Study:

• To review optical fiber sensors integrating molecular imprinting with SPR/LSPR techniques.
• To provide an overview of SPR/LSPR fundamentals on optical fibers.
• To discuss molecular imprinting technology, synthesis, and applications in analyte detection.

Main Methods:

• Fabrication of molecularly imprinted polymers (MIPs) for selective analyte recognition.
• Implementation of SPR/LSPR phenomena on optical fiber platforms.
• Integration of MIPs with optical fiber SPR/LSPR sensors for enhanced detection.

Main Results:

• Combined MIP-SPR/LSPR optical fiber sensors demonstrate high sensitivity and selectivity.
• The review summarizes various sensing methods for chemical and biological analytes.
• The synergy of these technologies enables rapid, real-time monitoring.

Conclusions:

• MIPs combined with SPR/LSPR on optical fibers present a powerful platform for sensitive and selective analyte detection.
• Challenges and future perspectives for developing advanced sensing methods are explored.
• This integrated approach holds significant promise for diagnostic and sensing applications.