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Performance Parameters and Characterizations of Nanocrystals: A Brief Review
Manasi M Chogale1, Vinod N Ghodake2, Vandana B Patravale3
1Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Nathalal Parekh Marg, Matunga, Mumbai-400019, India. manasi4190@gmail.com.
Pharmaceutics
|September 3, 2016
Summary
Formulating poorly soluble drugs as nanocrystals significantly enhances their bioavailability and clinical effectiveness. This approach involves detailed characterization of nanocrystal properties to optimize drug delivery.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery Systems
- Nanotechnology
Background:
- Poor drug solubility and bioavailability limit the efficacy of approximately 40% of new drug candidates.
- High log p, high melting point, and high dose requirements necessitate advanced formulation strategies for poorly soluble drugs.
Purpose of the Study:
- To explore the formulation of drugs as nanocrystals as a novel approach to overcome poor solubility.
- To detail the characterization techniques for evaluating nanocrystal properties and their impact on drug performance.
Main Methods:
- Nanocrystal formulation using top-down or bottom-up manufacturing methods.
- Evaluation of nanocrystal characteristics including particle size, saturation solubility, and dissolution velocity.
- Review of sophisticated techniques for nanocrystal characterization.
Main Results:
- Nanocrystals enhance drug bioavailability, reduce required dosage, and enable sustained drug release.
- Key nanocrystal characteristics (particle size, solubility, dissolution) directly influence improved drug performance.
- Various advanced techniques are available for comprehensive nanocrystal evaluation.
Conclusions:
- Nanocrystal technology offers a promising strategy to improve the clinical efficacy of poorly soluble drugs.
- Understanding and characterizing nanocrystal properties are crucial for optimizing drug delivery and therapeutic outcomes.
