Related Experiment Video
Updated: Mar 15, 2026
17:45
T-maze Forced Alternation and Left-right Discrimination Tasks for Assessing Working and Reference Memory in Mice
Published on: February 26, 2012
40.9K
Heterozygous Che-1 KO mice show deficiencies in object recognition memory persistence
Gisela Zalcman1, Nicoletta Corbi2, Maria Grazia Di Certo3
1Laboratorio de Neurobiología de la Memoria, Instituto de Fisiología, Biología Molecular y Neurociencias (IFIBYNE, UBA-CONICET), Buenos Aires, Argentina.
Neuroscience Letters
|September 4, 2016
Summary
The Che-1 protein plays a role in memory formation. Che-1 heterozygous mice show impaired long-term object recognition memory, suggesting Che-1
Area of Science:
- Neuroscience
- Molecular Biology
- Genetics
Background:
- Transcriptional regulation is crucial for long-term memory formation.
- Che-1 protein binds to the transcription factor NF-κB, implicated in memory.
- The precise role of Che-1 in memory processes requires investigation.
Purpose of the Study:
- To investigate the role of Che-1 in memory processes.
- To analyze the behavioral and memory performance of Che-1 heterozygous mice.
Main Methods:
- Generated Che-1(+/-) heterozygous mice.
- Assessed locomotor activity and thigmotactic behavior in an open field.
- Evaluated anxiety-like behavior using an elevated plus maze.
- Tested fear response via contextual fear conditioning (CFC).
- Analyzed object recognition memory using a novel object recognition (NOR) task.
Main Results:
- Che-1(+/-) mice exhibited normal locomotor activity, thigmotaxis, and anxiety-like behavior compared to wild-type (WT) mice.
- No significant differences were observed in CFC training or recall at 24h or 7 days.
- Object recognition memory was unimpaired at 24h but showed impaired persistence at 7 days in Che-1(+/-) mice.
Conclusions:
- Che-1 is involved in memory processes.
- Che-1 heterozygous mice display deficits in long-term object recognition memory persistence.
- This study provides the first evidence linking Che-1 to memory function.
Related Concept Videos
02:41Lethal Alleles
19.0K
Agouti: A Lethal Allele
Lucien Cuénot discovered lethal alleles in 1905 while studying the inheritance of coat color in mice. The agouti gene is responsible for the color of the coat in mice. This gene codes for an agouti-signaling protein, which is responsible for melanin distribution in mammals. The wild-type allele gives rise to gray-brown coat color in mice, while the mutant allele gives rise to yellow coat color. In addition to coat color, the agouti gene is associated with the yellow...
Lucien Cuénot discovered lethal alleles in 1905 while studying the inheritance of coat color in mice. The agouti gene is responsible for the color of the coat in mice. This gene codes for an agouti-signaling protein, which is responsible for melanin distribution in mammals. The wild-type allele gives rise to gray-brown coat color in mice, while the mutant allele gives rise to yellow coat color. In addition to coat color, the agouti gene is associated with the yellow...
19.0K
01:16In-vitro Mutagenesis
17.5K
To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.
17.5K