[The effect of immobilization stress on primary humoral immune response in white rats]

The influence of immobilization stress (24 h) was studied on the humoral immune response of white male rats of Wistar strain against thymus- dependent antigen(sheep erythrocytes). It was established that immunosuppression occurred during application of stress before immunization, while immunostimulation developed during application of the stress after immunization (during the effector phase of the immune response). These differences in the intensity of the immune response could be explained by the peculiarities of neuro-endocrine and immunologic changes in the tow variants of the experiment.