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In Vitro Model of Physiological and Pathological Blood Flow with Application to Investigations of Vascular Cell Remodeling
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A Real-Time Programmable Pulsatile Flow Pump for In Vitro Cardiovascular Experimentation.

Rahul Raj Mechoor1, Tyler Schmidt1, Ethan Kung2

  • 1Department of Mechanical Engineering, Clemson University, 252 Fluor Daniel EIB, Clemson, SC 29631

Journal of Biomechanical Engineering
|September 4, 2016
PubMed
Summary

Researchers developed a low-cost, programmable pulsatile flow pump for cardiovascular research. This device accurately reproduces physiologic flow waveforms, enhancing in vitro experiments and medical device testing.

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Area of Science:

  • Biomedical Engineering
  • Cardiovascular Research
  • Medical Device Testing

Background:

  • Benchtop in vitro experiments are crucial for studying the cardiovascular system and evaluating medical devices.
  • Accurate replication of physiologic flow waveforms is essential for the validity of these experimental methods.

Purpose of the Study:

  • To design, construct, and test a low-cost, programmable pulsatile flow pump.
  • To achieve accurate reproduction of physiologic flow waveforms for in vitro cardiovascular research and medical device testing.

Main Methods:

  • A gear pump actuated by an AC servomotor was employed.
  • An iterative feedback algorithm was developed to modify motor control waveforms.
  • The system was tested for flow rates up to 300 mL/s under varying downstream impedances.

Main Results:

  • The pump accurately reproduced desired physiologic flow waveforms within 2% normalized RMS error (for flow rates > 20 mL/s) after 4-7 feedback iterations.
  • The system demonstrated high accuracy across a range of loading conditions.
  • The developed pump is approximately 10% of the cost of commercial alternatives.

Conclusions:

  • The developed pulsatile flow pump offers a cost-effective and highly accurate solution for in vitro cardiovascular research.
  • Its programmability and compatibility with scientific software facilitate integration into automated experimental frameworks.
  • This device enhances the capabilities for medical device testing and physiological flow waveform reproduction.