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Related Concept Videos

Hand hygiene01:23

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Asepsis is the practice of preventing or breaking the chain of infection. The nurse employs aseptic techniques to prevent the spread of microorganisms and reduce the risk of diseases. Hand hygiene is the cornerstone of aseptic techniques and is classified into medical and surgical asepsis. Medical asepsis includes hand hygiene and the use of gloves. Surgical asepsis, or the sterile technique, refers to practices that render and keep objects and areas free of microorganisms.
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Healthcare Associated Infections II: Preventive Measures01:22

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Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
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The condition of being free from disease-causing living pathogens is asepsis. Aseptic techniques include a set of standard practices to achieve asepsis. An example is the regular environmental cleaning of all parts of the healthcare facility and hand hygiene at home before preparing or eating food. Medical and surgical asepsis in healthcare practice protects patients from harmful pathogens, minimizes the risk of contamination of susceptible sites, and reduces the risk of infection transmission.
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Surface Membrane Barriers01:18

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The skin and mucous membranes serve as the primary line of defense against pathogens by providing both physical and chemical protection. These barriers are essential in preventing the entry and establishment of microbes, thereby maintaining the integrity of the host.
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Bacterial signaling can occur within bacteria (intracellular) or between bacteria (intercellular). At times, a group of bacteria behaves like a community. To achieve this, they engage in quorum sensing, the perception of higher cell density that causes changes in gene expression. Quorum sensing involves both extracellular and intracellular signaling. The signaling cascade starts with a molecule called an autoinducer (AI). Individual bacteria produce AIs that move out of the bacterial cell...
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Intraoperative Strategy under Complex Vascular Adhesion for Laparoscopic Radical Resection of Bismuth-Corlette Type IIIb Perihilar Cholangiocarcinoma
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Antimicrobial-coated sutures to decrease surgical site infections: a systematic review and meta-analysis.

X Wu1, N Z Kubilay2, J Ren3

  • 1Department of Surgery, Jinling Hospital, Medical School of Nanjing University, 305 East Zhongshan Road, Nanjing, 210002, China.

European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology
|September 4, 2016
PubMed
Summary
This summary is machine-generated.

Antimicrobial sutures significantly reduced surgical site infection (SSI) risk in a meta-analysis. However, the evidence quality was moderate to low, with potential conflicts of interest noted in many studies.

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Area of Science:

  • Infectious Disease Epidemiology
  • Surgical Innovation
  • Evidence-Based Medicine

Background:

  • Surgical site infections (SSIs) are a significant concern in healthcare.
  • Antimicrobial-coated sutures are a potential intervention to reduce SSI rates.
  • Current World Health Organization (WHO) guidelines lack specific recommendations on antimicrobial sutures.

Purpose of the Study:

  • To evaluate the efficacy of antimicrobial-coated sutures versus non-coated sutures in preventing SSIs.
  • To inform recommendations for future WHO SSI prevention guidelines.

Main Methods:

  • Comprehensive literature search of multiple databases (Medline, Embase, Cinahl, Cochrane, WHO Global Health) from 1990-2015.
  • Meta-analysis using a random-effects model, including meta-regression and subgroup analyses.
  • Quality assessment of included studies using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) criteria.

Main Results:

  • Antimicrobial sutures demonstrated a significant reduction in SSI risk across both randomized controlled trials (RCTs) and observational studies (OBSs).
  • Consistent positive results were observed specifically for Vicryl Plus versus Vicryl sutures.
  • The effectiveness of antimicrobial coating was comparable across various suture, wound, and procedure types.

Conclusions:

  • Triclosan-coated sutures show potential in reducing surgical site infection risk.
  • The overall quality of evidence supporting antimicrobial sutures is moderate to low.
  • Further high-quality research is needed, considering potential conflicts of interest identified in existing studies.