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Renal protein excretion after exercise in man.
J R Poortmans1, L Rampaer, J C Wolfs
1Chimie Physiologique, Institut Supérieur d'Education Physique et de Kinésithérapie, Université Libre de Bruxelles, Belgium.
Summary
Post-exercise proteinuria shows a delayed recovery in kidney function, lasting up to 4 hours. This study details the kinetics of protein excretion after strenuous exercise.
Area of Science:
- Exercise Physiology
- Nephrology
- Biochemistry
Background:
- Strenuous exercise can transiently affect kidney function.
- Understanding the recovery kinetics of proteinuria is crucial for athletes and clinicians.
Purpose of the Study:
- To investigate the time course of proteinuria following exhaustive exercise.
- To determine the recovery kinetics of urinary total protein and albumin excretion.
- To explore potential factors influencing post-exercise proteinuria.
Main Methods:
- Thirteen men performed graded exhaustive cycle exercise.
- Blood and urine samples were collected during a 3-hour recovery period.
- Analysis included haematocrit, lactate, creatinine, total protein, and albumin.
Main Results:
- Urinary total protein and albumin excretion significantly increased post-exercise.
- Plasma volume normalized within 30-60 minutes, but proteinuria persisted.
- Proteinuria exhibited a logarithmic decline with a 54-minute half-life, normalizing in ~4 hours.
Conclusions:
- Kidney handling of protein recovers more slowly than other biochemical parameters post-exercise.
- Plasma volume reduction and dehydration do not appear to drive this proteinuria.
- This study provides precise kinetics of post-exercise proteinuria, indicating delayed renal recovery.