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Subcortical contributions to large-scale network communication.

Peter T Bell1, James M Shine2

  • 1University of Queensland Centre for Clinical Research, University of Queensland, Brisbane, QLD, Australia; Brain and Mind Centre, University of Sydney, Sydney, NSW, Australia.

Neuroscience and Biobehavioral Reviews
|November 7, 2016
PubMed
Summary
This summary is machine-generated.

The basal ganglia and thalamus are key hubs in brain networks, integrating diverse neural signals for higher brain functions. This research redefines the subcortex's role in large-scale brain communication.

Keywords:
Basal gangliaConnectivityDopamineHubIntegrationStriatumThalamus

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Area of Science:

  • Neuroscience
  • Network Science
  • Neuroanatomy

Background:

  • Higher brain functions depend on integrating distributed neuronal activity across large-scale brain networks.
  • Subcortical structures, particularly the basal ganglia and thalamus, are increasingly recognized for their role in network communication.

Purpose of the Study:

  • To review neuroanatomical and network science literature on the subcortex's contribution to large-scale brain networks.
  • To propose a new framework viewing the basal ganglia and thalamus as core circuits for neural signal integration.

Main Methods:

  • Examination of neuroanatomical literature.
  • Analysis of network science findings.
  • Synthesis of anatomical and network data.

Main Results:

  • Diverse neural systems converge within the basal ganglia and thalamus.
  • The basal ganglia and thalamus are identified as highly interconnected network hubs.
  • Evidence supports the subcortex's role in integrating functionally diverse neural signals.

Conclusions:

  • The basal ganglia and thalamus form a core subcortical circuit essential for large-scale brain network integration.
  • A subcortical-inclusive view is crucial for understanding human brain network communication.
  • Future research should address opportunities and challenges in this area.