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Updated: Mar 15, 2026

Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants
Published on: March 6, 2018
Effects of BPA on female reproductive function: The involvement of epigenetic mechanism
Stefania Santangeli1, Francesca Maradonna1, Ike Olivotto2
1Dipartimento Scienze della Vita e dell'Ambiente, Università Politecnica delle Marche, Via Brecce Bianche, 60131 Ancona, Italy; INBB Consorzio Interuniversitario di Biosistemi e Biostrutture, 00136 Roma, Italy.
Abstract:
Epigenetic modifications are classified as heritable and reversible chemical modifications of chromatin that do not cause changes in DNA sequence. Changes in epigenetic modifications can be caused by exposure to certain environmental factors, such as contaminants like bisphenol A (BPA). Bisphenol A is ubiquitous in the environment and produced in large quantities, and known to have hormone-like activity, whereby disrupting endocrine function. Because of evidence for disruption of sex steroid mediated pathways, there is a concern that BPA could have adverse effects on female reproduction. The purpose of this review is to summarize the effects of BPA on adult female reproduction with focus on epigenetic changes that can be heritable.
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