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Danazol and internal carotid artery thrombosis
M Corno1, G Vallar, G Scarlato
1Department of Neurology, University of Milan, Italy.
European Neurology
|January 1, 1989
Summary
A woman experienced an ischemic stroke after danazol treatment. The study discusses her thrombocytosis and its link to the thrombotic event.
Area of Science:
- Neurology
- Hematology
- Pharmacology
Background:
- Danazol, a synthetic androgen, is used to treat conditions like endometriosis and hereditary angioedema.
- Ischemic stroke is a significant neurological event often linked to thrombotic processes.
- Thrombocytosis, an elevated platelet count, can increase the risk of blood clots.
Observation:
- A 47-year-old woman developed a right hemisphere ischemic stroke.
- The stroke occurred following a two-month course of danazol therapy.
- The patient exhibited thrombocytosis during danazol treatment.
Findings:
- The case report details a potential association between danazol-induced thrombocytosis and ischemic stroke.
- Analysis focuses on the patient's elevated platelet count in relation to the thrombotic event.
Implications:
- This case highlights a potential adverse effect of danazol, necessitating careful monitoring for thrombotic events.
- Further research may be warranted to explore the mechanism linking danazol, thrombocytosis, and stroke risk.
- Clinicians should consider thrombocytosis as a potential risk factor in patients treated with danazol.