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Updated: Mar 15, 2026

Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells
Published on: April 7, 2017
Sarcomas of the Breast with a Spotlight on Angiosarcoma and Cystosarcoma Phyllodes
1Center for Sarcoma and Bone Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, D2105, Boston, MA 02115, USA.
Abstract:
Breast sarcomas are a diverse group of neoplasms arising from the nonepithelial and mesenchymal tissues of the breast. Their behaviors vary from the more indolent tumors like cystosarcoma phyllodes to the extremely aggressive angiosarcoma. They should be approached in a similar fashion to their soft tissue sarcoma counterparts in other locations and managed by multidisciplinary sarcoma specialists with attention to wide-margin surgical excision. The use of adjuvant chemotherapy is controversial and should be discussed on a case-by-case basis and preferably given in the context of a clinical trial.
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