Histological and histometrical changes of liver damage in rats after treatment with ethanol and carbon tetrachloride

A pretreatment of 30 to 52 weeks with a 10% (v/v) solution of ethanol did not bring about any distinct changes but increased the damaging effects on liver caused by an acute dose of carbon tetrachloride in rats. This was shown by the semiquantitative assessment of histological changes and by the measurement of hepatocyte nuclei. The results of both investigations are complementary to each other and show a correlation.