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Antiproliferative effects of 4',5'-unsaturated adenine nucleosides on leukemia L1210 cells in vitro
B Sheid1, L M Lerner, E Gaetjens
1Department of Pharmacology, State University of New York, Brooklyn 11203.
Abstract:
Several 4',5'-unsaturated adenine nucleosides were shown to have antiproliferative activity against L1210 leukemia cells in vitro. The active nucleosides were cytotoxic to the L1210 cells as demonstrated by Trypan Blue uptake. The cytotoxicity was not induced by alterations in the ribonucleoside and deoxyribonucleoside triphosphate levels of the L1210 cells.
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