Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Age distribution of circulating alpha-interferon.

S Shiozawa1, K Shiozawa, S Shimizu

  • 1Department of Medicine, Kobe University School of Medicine, Japan.

Experientia
|August 15, 1989
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Relationship between earlier introduction of tocilizumab and glucocorticoid-sparing effects on the acute phase of adult-onset Still's disease.

Scandinavian journal of rheumatology·2024
Same author

Hypophysitis identified on initial presentation of systemic lupus erythematosus: a case report and review of the literature.

Scandinavian journal of rheumatology·2021
Same author

Enterotoxigenicity of Staphylococcus aureus Strains Isolated from Chickens.

Journal of food protection·2019
Same author

Erratum to: Predictors of poor sleep quality in patients with systemic lupus erythematosus.

Clinical rheumatology·2017
Same author

Predictors of poor sleep quality in patients with systemic lupus erythematosus.

Clinical rheumatology·2017
Same author

The Japanese LupusPRO: A cross-cultural validation of an outcome measure for lupus.

Lupus·2016

Circulating alpha-interferon levels are lowest in children, peak in young adults, and gradually decrease with age. Even elderly individuals maintain detectable levels of this important immune protein.

Area of Science:

  • Immunology
  • Biochemistry
  • Human Physiology

Background:

  • Alpha-interferon (IFN-α) plays a crucial role in the innate immune response.
  • Understanding age-related changes in IFN-α levels is important for assessing immune function across the lifespan.

Purpose of the Study:

  • To quantify circulating alpha-interferon levels in healthy individuals across different age groups.
  • To investigate the relationship between age and plasma alpha-interferon concentrations.

Main Methods:

  • A sensitive radioimmunoassay technique was employed to measure plasma alpha-interferon.
  • Blood samples were collected from healthy individuals spanning various age ranges.

Main Results:

  • Plasma alpha-interferon levels were found to be low in children.

Related Experiment Videos

  • Levels peaked in young adults and subsequently declined gradually with advancing age.
  • In adults aged 30-39, mean levels were 0.201 ± 0.059 ng/ml in males and 0.184 ± 0.076 ng/ml in females.
  • Detectable levels of alpha-interferon were observed even in elderly participants.

    • Conclusions:

    • Circulating alpha-interferon concentrations exhibit a distinct age-dependent pattern in healthy individuals.
    • These findings highlight the dynamic nature of interferon levels throughout human life and suggest a baseline immune surveillance capacity in older adults.