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Updated: Mar 15, 2026

Inducing Apical Periodontitis in Mice

Inducing Apical Periodontitis in Mice

Published on: August 6, 2019

Association between Systemic Diseases and Apical Periodontitis.

Navid Khalighinejad¹, M Reza Aminoshariae², Anita Aminoshariae¹

¹Department of Endodontics, School of Dental Medicine, Case Western Reserve University, Cleveland, Ohio.

Journal of Endodontics

|September 5, 2016

Summary

Systemic diseases may be moderately linked to endodontic pathosis, a condition affecting the tooth's apex. Further research is needed to clarify this relationship and prevent apical periodontitis.

Keywords:

Correlation endodontic pathosis pathogenesis systematic review systemic diseases

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Last Updated: Mar 15, 2026

Inducing Apical Periodontitis in Mice

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Published on: August 6, 2019

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Isolation, Processing and Analysis of Murine Gingival Cells

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Published on: July 2, 2013

Area of Science:

Oral Health
Infectious Diseases
Immunology

Background:

The link between systemic diseases and periapical infections is not well-established.
Host-modifying factors in endodontic pathosis require further investigation.

Purpose of the Study:

To systematically review the association between host modifying factors and endodontic pathosis.
To explore potential relationships between systemic conditions and apical periodontitis.

Main Methods:

Comprehensive literature search across major databases (MEDLINE, Embase, Cochrane, PubMed).
Manual search of bibliographies of relevant articles and textbooks.
Independent review by two researchers with no disagreements.

Main Results:

Sixteen articles were included in the systematic review.
The overall quality of the included studies was moderate, with a moderate risk of bias.
Only three studies exhibited a low risk of bias.

Conclusions:

A moderate correlation may exist between certain systemic diseases and endodontic pathosis.
Further prospective and longitudinal research is necessary to define these interactions.
Understanding these links could help minimize systemic disease effects on apical periodontitis.