Death receptor 3 mediates necroptotic cell death
Sebastian Bittner1, Gertrud Knoll1, Martin Ehrenschwender2
1Institute of Clinical Microbiology and Hygiene, University Hospital Regensburg, Franz-Josef-Strauss-Allee 11, 93053, Regensburg, Germany.
Cellular and Molecular Life Sciences : CMLS
|September 5, 2016
Summary
Death Receptor 3 (DR3) triggers necroptotic cell death, not just apoptosis. This finding reveals DR3 as a novel necroptosis-inducing receptor, impacting inflammation and cell death research.
Area of Science:
- Immunology
- Cell Biology
- Molecular Biology
Background:
- Death Receptor 3 (DR3) is known for T cell co-stimulation and inflammation.
- Its role as a death receptor has been overshadowed by its involvement in inflammation-driven diseases.
Purpose of the Study:
- To investigate the cell death pathways mediated by Death Receptor 3 (DR3).
- To determine if DR3 can induce necroptosis in addition to apoptosis.
Main Methods:
- Investigated DR3-mediated cell death pathways.
- Examined necrosome assembly and dependence on RIP1 and RIP3.
- Assessed the role of reactive oxygen species in DR3-induced necroptosis.
Main Results:
- DR3 robustly triggers necroptotic cell death, alongside apoptosis.
- TL1A-induced, DR3-mediated necrosome assembly was observed.
- DR3-mediated necroptosis requires RIP1 and RIP3 but not reactive oxygen species.
Conclusions:
- DR3 is identified as a novel necroptosis-inducing death receptor.
- This discovery opens avenues for studying the physiological and pathological roles of DR3-mediated necroptosis.
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