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Updated: Mar 15, 2026
Role of Diffusion MRI Tractography in Endoscopic Endonasal Skull Base Surgery
Published on: July 5, 2021
Organ preservation with neoadjuvant chemoradiation in patients with orbit invasive sinonasal cancer otherwise
Mark J Amsbaugh1, Mehran Yusuf1, Craig Silverman1
1Department of Radiation Oncology, University of Louisville, Louisville, KY, USA.
Purpose:
We sought to determine if organ preservation (OP) with neoadjuvant chemoradiation (CRT) was feasible in patients with sinonasal cancer determined to require exenteration.
Materials And Methods:
Twenty patients were determined to require exenteration for definitive treatment from 2005 to 2014. Fourteen patients underwent OP and 6 patients received exenteration with adjuvant CRT. Exenteration free survival (EFS), locoregional control (LRC), progression-free survival (PFS), and overall survival (OS) were estimated.
Results:
Five patients (36%) receiving OP had complete disease response at time of surgery. With a median follow-up of 18.8 months, EFS was 62% at 2 years for patients undergoing OP. At 2 years, there were no significant differences in LRC, PFS or OS (all all p > 0.050) between the groups. Less grade 3 or greater toxicity was seen in patients undergoing OP (p = 0.003). Visual function was preserved in all patients undergoing OP.
Conclusion:
For patients with sinonasal cancer, OP may avoid exenteration, offering similar disease control and improved toxicity.
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